220047-80-3

Upstream product

• 151-50-8 potassium cyanide 
• 220047-71-2 (2S,4R)-2-Benzyloxymethyl-4-(toluene-4-sulfonyloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 212266-70-1 Toluene-4-sulfonic acid (S)-3-[((R)-2-benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-2-hydroxy-propyl ester 
• 212266-68-7 ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine 
• 212266-66-5 ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-carbamic acid tert-butyl ester 
• 212266-69-8 (S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol 
• 220047-69-8 (2R,3S,4R)-3-Benzenesulfonyl-2-benzyloxymethyl-4-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 220047-66-5 ((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol 
• 212266-67-6 ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amine 
• 220047-55-2 (R)-2-amino-3-benzyloxypropyl phenyl sulfone 
• 212266-65-4 (2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine 
• 220047-57-4 ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine 
• 175229-12-6 (R)-3-benzyloxy-2-(tert-butoxycarbonylamino)propyl phenyl sulfone 
• 100-39-0 benzyl bromide 

Downstream Products

• 220047-82-5 (2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-[2'-N-(tert-butoxycarbonyl)amino]ethylpyrrolidine 

Relevant academic research and scientific papers

Asymmetric synthesis of 4-substituted prolines as conformationally constrained amino acid analogues

Treatment of readily available chiral building block 1 with (2R)-2,3-O- isopropylideneglyceraldehyde (5) provides a new route for asymmetric synthesis of 2,4-disubstituted pyrrolidines. Several proline-amino acid chimeras: proline-leucine, proline-lysine, proline-arginine and proline- glutamic acid, are synthesized in highly diastereomerically pure forms.