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Syntheses and preventive effects of analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) on bone mineral loss in ovariectomized rats

DOI: 10.1016/S0968-0896(98)80025-4

Source and publish data:

Bioorganic and Medicinal Chemistry p. 2517 - 2523 (1998)

Update date:2022-09-26

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Authors:

Ono, YoshiyukiOno, Yoshiyuki

Kawase, AkiraKawase, Akira

Watanabe, HiroyoshiWatanabe, Hiroyoshi

Shiraishi, AyakoShiraishi, Ayako

Takeda, SatoshiTakeda, Satoshi

Higuchi, YoshinobuHiguchi, Yoshinobu

Sato, KatsuhikoSato, Katsuhiko

Yamauchi, TsuyoshiYamauchi, Tsuyoshi

Mikami, TetsuhiroMikami, Tetsuhiro

Kato, MasahiroKato, Masahiro

Tsugawa, NaokoTsugawa, Naoko

Okano, ToshioOkano, Toshio

Kubodera, NoboruKubodera, Noboru

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Article abstract of DOI:10.1016/S0968-0896(98)80025-4

Analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity. Copyright (C) 1998 Elsevier Science Ltd.

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Full text of DOI:10.1016/S0968-0896(98)80025-4

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