Bioorganic and Medicinal Chemistry p. 2517 - 2523 (1998)
Update date:2022-09-26
Topics:
Ono, Yoshiyuki
Kawase, Akira
Watanabe, Hiroyoshi
Shiraishi, Ayako
Takeda, Satoshi
Higuchi, Yoshinobu
Sato, Katsuhiko
Yamauchi, Tsuyoshi
Mikami, Tetsuhiro
Kato, Masahiro
Tsugawa, Naoko
Okano, Toshio
Kubodera, Noboru
Analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity. Copyright (C) 1998 Elsevier Science Ltd.
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