220299-35-4

Basic information

• Product Name: 2-Naphthalenecarbonitrile, 6-[(1E)-2-phenylethenyl]-
• CAS NO: 220299-35-4
• Molecular Formula: C19H13N
• Molecular Weight: 255.319
• Mol File: 220299-35-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Naphthalenecarbonitrile, 6-[(1E)-2-phenylethenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthalenecarbonitrile, 6-[(1E)-2-phenylethenyl]-(220299-35-4)
• EPA Substance Registry System: 2-Naphthalenecarbonitrile, 6-[(1E)-2-phenylethenyl]-(220299-35-4)

Safety Data

• Hazardous Substances Data: 220299-35-4(Hazardous Substances Data)

Upstream product

• 1255871-55-6 6-bromonaphthalene-2-carboxamide 
• 100-42-5 styrene 
• 91065-17-7 6-bromo-naphthalene-2-carbonitrile 
• 5773-80-8 6-bromo-2-naphthoic acid 
• 3375-31-3 palladium diacetate 
• 219873-03-7 6-(hydroxymethyl)-2-naphthonitrile 
• 5088-91-5 6-cyano-naphthalene-2-carboxylic acid methyl ester 
• 56358-46-4 6-bromomethyl-2-naphthalenecarbonitrile 
• 100-52-7 benzaldehyde 
• 371222-24-1 diethyl (6-cyano-2-naphthyl)methylphosphonate 

Downstream Products

• 220299-36-5 6-[2-(Phenyl)ethyl]-2-naphthalenecarbonitrile 

Relevant articles and documents

Novel amidrazone derivatives: Design, synthesis and activity evaluation

A series of new 6-styryl-naphthalene-2-amidrazone derivatives were synthesized and evaluated as potential ASIC1a inhibitors. Among them, compound 5e showed the most activity to inhibit [Ca2+]i. elevation in acid-induced articular chondrocytes. Together with the important role of ASIC1a in the pathogenesis of tissue acidification diseases including rheumatoid arthritis, these results might provide a meaningful hint or inspiration in developing drugs targeting at tissue acidification diseases.

Urokinase inhibitors

Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.