220299-35-4Relevant academic research and scientific papers
Novel amidrazone derivatives: Design, synthesis and activity evaluation
Zhou, Hua,Wang, Zhi Sen,Liu, Xin Hua,Chen, Fei Hu
, p. 3158 - 3165 (2018)
A series of new 6-styryl-naphthalene-2-amidrazone derivatives were synthesized and evaluated as potential ASIC1a inhibitors. Among them, compound 5e showed the most activity to inhibit [Ca2+]i. elevation in acid-induced articular chondrocytes. Together with the important role of ASIC1a in the pathogenesis of tissue acidification diseases including rheumatoid arthritis, these results might provide a meaningful hint or inspiration in developing drugs targeting at tissue acidification diseases.
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties
Bruncko, Milan,McClellan, William J.,Wendt, Michael D.,Sauer, Daryl R.,Geyer, Andrew,Dalton, Christopher R.,Kaminski, Michele A.,Weitzberg, Moshe,Gong, Jane,Dellaria, Joseph F.,Mantei, Robert,Zhao, Xumiao,Nienaber, Vicki L.,Stewart, Kent,Klinghofer, Vered,Bouska, Jennifer,Rockway, Todd W.,Giranda, Vincent L.
, p. 93 - 98 (2007/10/03)
A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus p
Urokinase inhibitors
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, (2008/06/13)
Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
Ukokinase inhibitors
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, (2008/06/13)
Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
