220327-45-7

Upstream product

• 100-52-7 benzaldehyde 
• 83-42-1 6-chloro-2-nitrotoluene 
• 31912-08-0 (2-chloro-6-nitro-phenyl)-acetic acid 
• 89277-98-5 2-(2-chloro-6-nitrophenyl)acetonitrile 
• 56433-01-3 2-chloro-6-nitrobenzyl bromide 

Downstream Products

• 220327-47-9 3-(4-chloro-2-phenylindol-1-yl)propionic acid 
• 220327-46-8 4-chloro-1-(2-cyanoethyl)-2-phenylindole 
• 220327-49-1 9-Chloro-2-phenyl-4,5-dihydro-pyrrolo[3,2,1-ij]quinolin-6-one 
• 66354-66-3 4-chloro-2-phenyl-1H-indole 

Relevant academic research and scientific papers

Synthesis of new 3-substituted 1-hydroxy-2-phenylindoles using sulfur-containing nucleophiles

The synthesis of new 3-[(acyl(or alkyl)thio)methyl]-1-hydroxy-2-phenylindoles 1 are presented. The substrates 2 obtained by each efficient three-step synthesis were treated, in the presence of SnCl2·2H2O, with nucleophiles such as th

Synthesis and diuretic activity of 4,5-dihydro-6H-imidazo[4,5,1- ij]quinoline-6-one 6-oxime-O-sulfonic acid derivatives

Using our previously reported 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)- 4(1H)-quinolinone 4-oxime-O-sulfonic acid potassium salt la (M17055) as a lead, a series of tricyclic (2a-o, 3, 4, 5) and tetracyclic (6) quinolinone oxime O-sulfonic acid derivatives were synthesized by ring annulation of the 1-(2-methylbenzoyl) moiety to the quinolinone skeleton. They were compared with furosemide and compound 1a for diuretic activity in dogs; some tricyclic 4,5-dihydro-6H-imidazo[4,5,1-ij]quinoline-6-one 6-oxime-O-sulfonic acid derivatives showed diuretic activity comparable (2c,e) or superior (2m) to the lead compound 1a. These results are discussed on the basis of a comparison of the conformational and electronic characteristics of the relevant compounds with the aid of computer graphics.