31912-08-0

Basic information

• Product Name: (2-chloro-6-nitrophenyl)acetic acid
• Synonyms: benzeneacetic acid, 2-chloro-6-nitro-
• CAS NO: 31912-08-0
• Molecular Formula: C₈H₆ClNO₄
• Molecular Weight: 215.5905
• Mol File: 31912-08-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 361.2°C at 760 mmHg
• Flash Point: 172.2°C
• Density: 1.532g/cm³
• Vapor Pressure: 7.56E-06mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: (2-chloro-6-nitrophenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chloro-6-nitrophenyl)acetic acid(31912-08-0)
• EPA Substance Registry System: (2-chloro-6-nitrophenyl)acetic acid(31912-08-0)

Safety Data

• Hazardous Substances Data: 31912-08-0(Hazardous Substances Data)

Usage

General Description

(2-chloro-6-nitrophenyl)acetic acid, also known as 2-chloro-6-nitrobenzeneacetic acid, is a chemical compound with the molecular formula C8H6ClNO4. It is a derivative of acetic acid, with a nitro group and a chlorine atom attached to a phenyl ring. (2-chloro-6-nitrophenyl)acetic acid is commonly used in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It has also been studied for its potential use as an antimicrobial and anticancer agent. Additionally, (2-chloro-6-nitrophenyl)acetic acid is a halogenated aromatic compound, which means it can have potential environmental and health impacts if not handled and disposed of properly.

Upstream product

• 3209-22-1 1,2-Dichloro-3-nitrobenzene 
• 105-53-3 diethyl malonate 
• 56433-01-3 2-chloro-6-nitrobenzyl bromide 
• 83-42-1 6-chloro-2-nitrotoluene 
• 95-92-1 oxalic acid diethyl ester 
• 36892-19-0 (2-chloro-6-nitro-phenyl)-pyruvic acid 
• 89277-98-5 2-(2-chloro-6-nitrophenyl)acetonitrile 

Downstream Products

• 102493-68-5 2-(2-chloro-6-nitrophenyl)-ethanol 
• 100376-53-2 2-(2-amino-6-chlorophenyl)ethyl alcohol 
• 855423-46-0 4-chloro-3-(4-hydroxy-benzylidene)-indolin-2-one 
• 119209-37-9 2-(6-Chlor-2-nitrobenzyl)nicotinsaeure-ethylester 
• 119209-31-3 (Z)-3-Amino-4-(6-chlor-2-nitrophenyl)crotonsaeure-ethylester 
• 220327-47-9 3-(4-chloro-2-phenylindol-1-yl)propionic acid 
• 220327-46-8 4-chloro-1-(2-cyanoethyl)-2-phenylindole 
• 220327-49-1 9-Chloro-2-phenyl-4,5-dihydro-pyrrolo[3,2,1-ij]quinolin-6-one 
• 220327-45-7 2-(2-chloro-6-nitrophenyl)acetophenone 
• 66354-66-3 4-chloro-2-phenyl-1H-indole 
• 6127-12-4 (6-Nitro-2-chlor-phenyl)-aceton 
• 119209-28-8 4-(6-Chlor-2-nitrophenyl)acetessigsaeure-ethylester 
• 97522-09-3 methyl 2-(2-chloro-6-nitrophenyl)acetate 
• 20870-77-3 4-chloroindolin-2-one 

Relevant articles and documents

Synthesis and diuretic activity of 4,5-dihydro-6H-imidazo[4,5,1- ij]quinoline-6-one 6-oxime-O-sulfonic acid derivatives

Using our previously reported 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)- 4(1H)-quinolinone 4-oxime-O-sulfonic acid potassium salt la (M17055) as a lead, a series of tricyclic (2a-o, 3, 4, 5) and tetracyclic (6) quinolinone oxime O-sulfonic acid derivatives were synthesized by ring annulation of the 1-(2-methylbenzoyl) moiety to the quinolinone skeleton. They were compared with furosemide and compound 1a for diuretic activity in dogs; some tricyclic 4,5-dihydro-6H-imidazo[4,5,1-ij]quinoline-6-one 6-oxime-O-sulfonic acid derivatives showed diuretic activity comparable (2c,e) or superior (2m) to the lead compound 1a. These results are discussed on the basis of a comparison of the conformational and electronic characteristics of the relevant compounds with the aid of computer graphics.