220352-38-5

Usage

Uses

(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine is a useful building block

InChI:InChI=1/C9H9F2N/c10-7-2-1-5(3-8(7)11)6-4-9(6)12/h1-3,6,9H,4,12H2/t6-,9+/m0/s1

Upstream product

• 1402222-66-5 trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine hydrochloride 
• 898752-22-2 C₁₂H₁₂F₂O₃ 
• 1267369-02-7 isopropyl 4-(3,4-difluorophenyl)-4-oxobutanoate 
• 1248202-12-1 4-keto-4-(3,4-difluorophenyl)butyric acid methyl ester 
• 1006614-50-1 (1R,2R)-2-(3,4-difluorophenyl)cyclopropylcarboxylic acid 
• 367-11-3 ortho-difluorobenzene 
• 1345413-23-1 (1R)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol 
• 1345413-24-2 trans-(1S,2R)-2-(3,4-difluorophenyl)-1-nitrocyclopropane 
• 1215969-79-1 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one 
• 218430-47-8 (E)-methyl 3-(3,4-difluorophenyl)acrylate 
• 112897-97-9 (E)-3-(3,4-difluorophenyl)acrylic acid 
• 376608-66-1 (E)-3-(3,4-difluorophenyl)acryloyl chloride 

Downstream Products

• 1427523-83-8 N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide 
• 1427523-91-8 benzyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate 
• 1427523-92-9 benzyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate 
• 1427523-80-5 tert-butyl (5-amino-6-(((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)-2-(propylthio) pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate 
• 1427523-82-7 methyl 2-(((3aR,4S,6R,6aS)-6-(7-((tert-butoxycarbonyl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate 
• 1427523-85-0 N-(6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)-N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzenesulfonamide 
• 1427523-87-2 N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-N-(6-(((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)-5-nitro-2-(propylthio)pyrimidin-4-yl)-4-methylbenzenesulfonamide 
• 1427523-88-3 N-(5-amino-6-(((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)-2-(propylthio)pyrimidin-4-yl)-N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzenesulfonamide 
• 1427523-89-4 N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-N-(3-((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-4-methylbenzenesulfonamide 
• 1427523-79-2 tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)(6-(((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)-5-nitro-2-(propylthio)pyrimidin-4-yl)carbamate 
• 1350749-64-2 tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate 
• 1427523-93-0 6-chloro-N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-5-nitro-2-(propylthio)pyrimidin-4-amine 
• 274693-27-5 ticagrelor 

Relevant academic research and scientific papers

Preparation method of phenyl-containing compound

The present invention discloses a method for preparing an phenyl-containing compound. The present invention provides a method for preparing a compound shown in formula I, comprising the following steps: in the presence of formamide or acetamide, in the pr

Preparation method of chiral aromatic cyclopropylamine and salt thereof and intermediate used in preparation method

The embodiment of the invention provides a preparation method of a compound as shown in a formula I or salt thereof, which comprises the following steps: (1) reacting a compound as shown in a formulaVI with a compound as shown in a formula VII in a first

Preparation method of ticagrelor chiral intermediate

The invention discloses a preparation method of a ticagrelor chiral intermediate. The ticagrelor chiral intermediate is trans-(1R, 2S)-2-(3, 4-difluorophenyl) cyclopropylamine. The method includes thesteps: taking cyclopropylamine as a raw material; perfo

Synthetic method for ticagrelor intermediate (1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine

The invention discloses a synthetic method for a ticagrelor intermediate (1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine. The method comprises the following steps: (5H)-furan-2-one is taken as a starting raw material, the (5H)-furan-2-one and a 3,4-difluor

A process for preparing (1 R, 2 S) - 2 - (3, 4 - difluorophenyl) amine method

The invention relates to a method for preparation of (1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine represented by the formula I. The method adopts 1-(3,4-difluorophenyl)ethylene as a raw material, a dextro-laevo isomer of the formula I is obtained succes

(1 R, 2 S) - 2 - (3, 4 - difluorophenyl) amine ·D - mandelic acid salt preparation method

The invention discloses a preparation method of (1R,2S)-2-(3,4-difluorophenyl) rolicyprine.D-mandelate. The preparation method comprises the following steps: carrying out cyclopropanation on a compound shown in a formula V to obtain a compound shown in a formula IV; carrying out amide generation and Hofmann degradation to obtain a compound shown in a formula II; and performing salification with D-mandelic acid to obtain a compound shown in a formula I. The compound shown in the formula V is prepared in a way that a compound shown in a structure formula VI is subjected to CBS asymmetric reduction reaction, wherein a catalyst for the CBS asymmetric reduction reaction is a compound shown in a structural formula VII, and a reduction agent for the CBS asymmetric reduction reaction can be borane-tetrahydrofuran or borane-N,N-diethyl phenylamine.

for standard auspicious Luo river intermediate preparation method

The inventiondiscloses a preparation method of ticagrelor. The method comprises the following steps: (1) reducing a compound shown in a formula III in the presence of a proton source provided by sodium borohydride or potassium borohydride and diethyl aniline hydrochloride to obtain a compound shown in a formula IV; (2) reacting the compound IV in the presence of alkali to generate a compound VI; (3) hydrolyzing the compound VI without purification to generate a compound VII; (4) reacting the compound VII to generate acyl chloride, reacting the acyl chloride to generate formamide, thus obtaining a compound shown in a formula IX; and (5) carrying out Hofmann rearrangement on the compound IX to obtain a compound shown in a formula II. Regents used in the method are nontoxic, harmless, environmentally friendly and low in price; the used key reagents can be recycled. Therefore, the method is applicable to industrial production.

Method for synthesizing (1R,2S)-1-amino-(3,4-difluorophenyl)-cyclopropane

The present invention relates to a method for synthesizing (1R,2S)-1-amino-(3,4-difluorophenyl)-cyclopropane. The method is characterized by comprising: 1) mixing 3,4-difluorobenzaldehyde and bis(pinacolato)diboron in tetrahydrofuran to obtain a mixture A

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An important intermediate for card Grey (1R, 2S) - 2 - (3,4-di-fluorophenyl) method for the preparation of cyclopropylamines

The invention relates to a method for preparing important midbody (1R,2S)-2-(3,4-difluorinated phenyl) cyclopropylamine of ticagrelor. The method mainly comprises the following steps: performing cyclopropane reaction on camphor sulfonium ylide I and acryl