220623-07-4 Usage
General Description
The chemical (1S,2S,5R)-3-Boc-2-[(tert-butyldimethylsilyloxy)methyl]-4-oxo-3-azabicyclo[3.1.0]hexane is a derivative of the bicyclic compound 3-azabicyclo[3.1.0]hexane. It contains a Boc (tert-butoxycarbonyl) protecting group, as well as a tert-butyldimethylsilyloxy (TBDMS) protecting group on a hydroxyl group. These protecting groups serve to temporarily block the reactivity of certain functional groups during chemical reactions. (1S,2S,5R)-3-Boc-2-[(tert-butyldimethylsilyloxy)methyl]-4-oxo-3-azabicyclo[3.1.0]hexane can be used as an intermediate in organic synthesis, particularly in the preparation of complex molecules with multiple stereocenters.
Check Digit Verification of cas no
The CAS Registry Mumber 220623-07-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,6,2 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 220623-07:
(8*2)+(7*2)+(6*0)+(5*6)+(4*2)+(3*3)+(2*0)+(1*7)=84
84 % 10 = 4
So 220623-07-4 is a valid CAS Registry Number.
220623-07-4Relevant articles and documents
CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS
-
, (2009/01/24)
The present invention is directed to cyclopropyl proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
NEW ROUTES TO THE SYNTHESES OF CIS-α-(CARBOXYCYCLOPROPYL)GLYCINES FROM L-GLUTAMIC ACID. CONFORMATIONALLY RESTRICTED ANALOGUES OF THE EXCITATORY NEUROTRANSMITTER L-GLUTAMIC ACID
Shimamoto, Keiko,Ohfune, Yasufumi
, p. 3803 - 3804 (2007/10/02)
Potent neuroactive amino acids, (2S,2S,4R) and (2S,3R,4S) isomers of α-(carboxycyclopropyl)glycines (CCG-III and CCG-IV), were synthesized from L-glutamic acid via a palladium(II) catalyzed cyclopropanation of the α,β-unsaturated pyrrolidone and γ-amino-δ-lactone derivatives, respectively.
