220657-22-7

Upstream product

• 126587-57-3 (3S,4R,5S)-4-Amino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (1S,2S,3R)-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-2-methoxymethoxy-3-methyl-butyl ester 
• 220657-11-4 (2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 
• 220657-18-1 (2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester 
• 220657-13-6 (2S,3R)-3-[(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-phenyl-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester 
• 220657-15-8 (2S,3R)-2-tert-Butoxycarbonylamino-3-((S)-2-methylamino-3-phenyl-propionyloxy)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester 
• 126587-71-1 Boc-threonine [(2-trimethylsilyl)ethoxy]methyl ester 
• 2899-07-2 (S)-N-benzyloxycarbonyl-N-methyl-phenyl alanine 
• 1161-13-3 N-Cbz-L-Phe 

Downstream Products

• 220657-25-0 N--L-leucyl>-L-prolyl>-N-methyl-L-phenylalanine ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3S)-1-isopropyl-2-(methoxy... 
• 220657-24-9 N--L-leucyl>-L-prolyl>-N-methyl-L-phenylalanine ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isopropyl-2-... 

Relevant academic research and scientific papers

Synthesis and biological activities of [N-MeLeu5]- and [N-MePhe5]- didemnin B

Based on information from X-ray, NMR, and SAR data, the N,O-diMeTyr5 unit of didemnin B was believed to be important for biological activity. To determine the importance of aromaticity and the role of the methoxy group in this unit, two analogs