220657-25-0Relevant articles and documents
Synthesis and biological activities of [N-MeLeu5]- and [N-MePhe5]- didemnin B
Pfizenmayer, Amy J.,Ramanjulu, Joshi M.,Vera, Matthew D.,Ding, Xiaobin,Xiao, Dong,Chen, Wei-Chuan,Joullie, Madeleine M.
, p. 313 - 334 (2007/10/03)
Based on information from X-ray, NMR, and SAR data, the N,O-diMeTyr5 unit of didemnin B was believed to be important for biological activity. To determine the importance of aromaticity and the role of the methoxy group in this unit, two analogs