22072-35-1

Basic information

• Product Name: 2,3,6-trimethyl-1H-indole
• Synonyms: 1H-indole, 2,3,6-trimethyl-; 2,3,6-Trimethyl-1H-indole
• CAS NO: 22072-35-1
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.2276
• Mol File: 22072-35-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 292.7°C at 760 mmHg
• Flash Point: 123.8°C
• Density: 1.056g/cm³
• Vapor Pressure: 0.00316mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 2,3,6-trimethyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,6-trimethyl-1H-indole(22072-35-1)
• EPA Substance Registry System: 2,3,6-trimethyl-1H-indole(22072-35-1)

Safety Data

• Hazardous Substances Data: 22072-35-1(Hazardous Substances Data)

Usage

General Description

2,3,6-trimethyl-1H-indole is a chemical compound with a molecular formula C11H13N. It is a derivative of indole, which is a heterocyclic aromatic organic compound. 2,3,6-trimethyl-1H-indole is a pale yellow liquid at room temperature and is commonly used in the production of fragrances and perfumes. It has a strong, floral odor and is often added to personal care products, such as soaps, lotions, and shampoos. 2,3,6-trimethyl-1H-indole is also used as a flavoring agent in food and beverages. Additionally, it has been studied for its potential biological activities, including its antimicrobial and antioxidant properties.

Upstream product

• 117668-69-6 3-(m-tolylamino)butan-2-one 
• 108-44-1 1-amino-3-methylbenzene 
• 814-75-5 3-bromo-butanone 
• 513-85-9 2.3-butanediol 
• 637-04-7 (3-methylphenyl)hydrazine hydrochloride 
• 78-93-3 butanone 

Downstream Products

• 1370410-12-0 C₁₈H₁₆INO 
• 1370410-32-4 C₁₈H₁₆BrNO 
• 165614-76-6 5-amino-2,3,6-trimethylindole 
• 127396-17-2 N-(2-acetyl-5-methylphenyl)acetamide 
• 289685-81-0 2,3,6-trimethyl-5-nitroindole 

Relevant articles and documents

Synthesis of indoles through acceptorless dehydrogenative coupling catalyzed by nickel on silica-alumina

The high atom-economical formation of indoles from anilines and diols was described with affordable and easy to handle Ni/SiO2-Al2O3. After optimization, 2,3-dimethylindole was isolated with an excellent 98% yield in neat conditions. The scope of the reaction was studied and 13 indoles were isolated in 16–80% yields.

Efficient construction of fused indolines with a 2-quaternary center via an intramolecular heck reaction with a low catalyst loading

An efficient construction of fused indolines with a 2-quaternary center through a palladium-catalyzed intramolecular Heck reaction of N-(2(2-halobenzoxyl)-2,3-disubstituted indoles is disclosed. This protocol provided a straightforward access to diverse fused indolines with good functional group tolerance.