22090-26-2

Basic information

• Product Name: 1-(4-BROMOPHENYL)PYRROLIDINE
• Synonyms: 1-(4-BROMOPHENYL)PYRROLIDINE;N-(4-BROMOPHENYL)PYRROLIDINE;1-(4-Bromophenyl)pyrrolidine 97+%;Pyrrolidine, 1-(4-broMophenyl)-;1-Bromo-4-pyrrolidinobenzene
• CAS NO: 22090-26-2
• Molecular Formula: C₁₀H₁₂BrN
• Molecular Weight: 226.11
• Product Categories: Miscellaneous
• Mol File: 22090-26-2.mol
• Article Data: 29

Chemical Properties

• Melting Point: 105.0 to 109.0 °C
• Boiling Point: 306.1°Cat760mmHg
• Flash Point: 138.9°C
• Appearance: /
• Density: 1.411g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.81±0.40(Predicted)
• CAS DataBase Reference: 1-(4-BROMOPHENYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENYL)PYRROLIDINE(22090-26-2)
• EPA Substance Registry System: 1-(4-BROMOPHENYL)PYRROLIDINE(22090-26-2)

Safety Data

• Hazardous Substances Data: 22090-26-2(Hazardous Substances Data)

Usage

General Description

1-(4-Bromophenyl)pyrrolidine is a chemical compound consisting of a pyrrolidine ring and a 4-bromophenyl group. It is commonly used in the synthesis of pharmaceuticals and other organic compounds. This chemical is considered a pyrrolidine derivative and can be used as a building block in organic synthesis. It is a colorless to pale yellow liquid and has a molecular weight of 229.15 g/mol. 1-(4-Bromophenyl)pyrrolidine is mainly used in the production of various chemicals and pharmaceuticals due to its versatile nature and ability to serve as a key intermediate in the synthesis of complex molecules.

InChI:InChI=1/C10H12BrN/c11-9-3-5-10(6-4-9)12-7-1-2-8-12/h3-6H,1-2,7-8H2

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 229009-41-0 (4-(pyrrolidin-1-yl)phenyl) boronic acid 
• 108-86-1 bromobenzene 
• 30438-95-0 N,N-diallyl-4-bromobenzenamine 
• 7661-32-7 1-(4-bromophenyl)pyrrolidin-2-one 
• 2393-23-9 4-methoxy-benzylamine 
• 123-75-1 pyrrolidine 
• 106-40-1 4-bromo-aniline 
• 589-87-7 1,4-bromoiodobenzene 
• 66107-30-0 4-bromophenyl trifluoromethanesulfonate 
• 4096-21-3 N-phenylpyrrolidine 
• 5467-74-3 4-Bromophenylboronic acid 
• 68388-05-6 O-benzoyl-N-hydroxylpyrrolidine 

Downstream Products

• 307927-02-2 4-morpholino-4'-pyrrolidinotriphenylmethanol 
• 307927-01-1 4-piperidino-4'-pyrrolidinotriphenylmethanol 
• 307927-08-8 4-(N-methylpiperazino)-4'-pyrrolidinotriphenylmethanol 
• 22090-27-3 4-(pyrrolidine-1-yl)benzoic acid 
• 88799-17-1 1-(4-Bromo-phenyl)-pyrrolidine; compound with bromine 
• 88799-20-6 N-(4-Bromphenyl)-N-methyl-pyrrolidinium-bromid 
• 1098299-25-2 1-(4-(thiophen-2-yl)phenyl)pyrrolidine 

Relevant articles and documents

Dehydrogenation/(3+2) Cycloaddition of Saturated Aza-Heterocycles via Merging Organic Photoredox and Lewis Acid Catalysis

Herein, we report a photoinduced dehydrogenation/(3+2) cycloaddition reaction by merging organic photoredox and Lewis acid catalysis, providing a straightforward and efficient approach for directly installing a benzofuran skeleton on the saturated aza-heterocycles. In this protocol, we also describe a novel organic photocatalyst (t-Bu-DCQ) with the advantages of a wider redox potential, easy synthesis, and a low price. Furthermore, the stepwise activation mechanism of dual C(sp3)-H bonds was demonstrated by a series of experimental and computational studies.

Aryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application

Synthesis, temperature-dependent NMR structure investigation and utilization of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In our study, we demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.

Preparation method for series synthesis of phenylpyrrolidine derivative under metal catalysis

The invention relates to a preparation method for series synthesis of a phenylpyrrolidine derivative under metal catalysis. The structural formula of the prepared phenylpyrrolidine derivative is shownin the figure 1. The preparation method comprises the following steps: preparing an N, N-diallyl aniline compound, a Grubbs catalyst, reduced iron powder and a reaction solvent, setting the reactiontemperature to be 40 DEG C, and fully stirring and reacting for 8-10 hours in a hydrogen atmosphere; and quenching after the reaction is monitored by TLC, extracting by using an organic solvent, drying, filtering, concentrating, and purifying by column chromatography to obtain the phenylpyrrolidine derivative with the yield of 62-81%. According to the method, the phenylpyrrolidine derivative is synthesized through one-pot series connection, raw materials are easy to obtain, operation is easy, repeatability is good, reaction conditions are mild, and the method is suitable for industrial production.