22091-49-2

Usage

Uses

Used in Pharmaceutical Research:
4-(4-Bromo-phenyl)-2-methyl-oxazole is used as a building block for the synthesis of various biologically active molecules. It is valued for its antimicrobial, antifungal, and anti-inflammatory properties, making it a potential candidate for the development of new pharmaceutical drugs.
Used in Agrochemicals Synthesis:
4-(4-Bromo-phenyl)-2-methyl-oxazole is also investigated for its potential use as an intermediate in the synthesis of agrochemicals, contributing to the development of new products in this industry.
Used in Specialty Chemicals Synthesis:
Furthermore, 4-(4-Bromo-phenyl)-2-methyl-oxazole has been explored for its application as an intermediate in the synthesis of specialty chemicals, indicating its versatility and potential across a range of chemical applications.

Upstream product

• 60-35-5 acetamide 
• 99-73-0 para-bromophenacyl bromide 
• 75-05-8 acetonitrile 
• 59862-55-4 p-bromoacetophenone oxime 
• 177750-12-8 N-{1-(4-bromophenyl)vinyl}acetamide 
• 7500-37-0 2-(4-bromophenyl)-2-oxoethyl acetate 
• 108-86-1 bromobenzene 

Downstream Products

• 176961-20-9 N-(3,4-Dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-methyl-4-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 78164-40-6 4-(4-Bromo-phenyl)-2-methyl-5-nitro-oxazole 
• 101273-56-7 4-([1,1'-biphenyl]-4-yl)-2-methyloxazole 

Relevant academic research and scientific papers

Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors

Oxazole derivatives are important medicinal compounds which are inhibitors of various enzymes such as NPP1, NPP2, NPP3, tyrosine kinase, dipeptidyl-peptidase IV, cyclooxygenase-2, and protein tyrosine phosphatase. In this study, an extensive range of new

Hypervalent iodane mediated reactions of: N -acetyl enamines for the synthesis of oxazoles and imidazoles

A hypervalent iodane reagent used for the intramolecular cyclization of N-acetyl enamines and intermolecular cyclocondensation of enamines and nitriles was investigated. The reaction was performed under mild conditions and gave oxazoles and imidazoles, respectively, in moderate to excellent yields. This transformation exhibits good reactivity, selectivity and functional group tolerance. The selectivity of the intra- or intermolecular reaction is dependent on the structure of N-acetyl enamines.

Amino propylene glycol derivatives, its preparation method and its pharmaceutical composition and use thereof

The invention discloses a class of amino propanediol derivatives, a preparation method, drug compositions and uses thereof, and particularly relates to a class of new immunoloregulation agents represented by a general formula (I), a preparation method, drug compositions containing the immunoloregulation agents, and especially uses of the immunoloregulation agents as immunoloregulation drugs. The compound with characteristics of excellent treatment effect and low toxicity can be used in the fields of immunologic derangement and immunosuppression, and can further be used for treatment of hypoimmunity, organ transplant rejection and autoimmune diseases. The formula I is defined in the instruction.

Copper-catalyzed direct synthesis of iodoenamides from ketoximes

Iodide in copper's pathway: A new, efficient, and practical copper-catalyzed synthesis of Z-iodoenamides from readily available ketoximes has been developed (see scheme). The reaction was believed to proceed through a single-electron-transfer pathway. The corresponding Z-iodoenamides have been applied to the synthesis of substituted oxazoles, dienes, β-phenoxyl enamides, eneynes, β-acylenamides, and pyrroles (DCE=1,2-dichloroethane). Copyright

PYRROLIDINE DERIVATIVES AS HISTAMINE RECEPTORS LIGANDS

The present invention relates to pyrrolidine derivatives of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS

The present invention relates to novel piperidine ether derivatives having affinity for the histamine H3 receptor, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

NOVEL COMPOUNDS

The present invention relates to novel diazepanyl derivatives of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

PIPERAZINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISEASES

The present invention relates to novel piperidine carbonyl piperazine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.