221056-83-3Relevant academic research and scientific papers
Total synthesis of (±)-Wortmannin
Mizutani, Takashi,Honzawa, Shinobu,Tosaki, Shin-ya,Shibasaki, Masakatsu
, p. 4680 - 4682 (2002)
A potent and specific phosphoinositide 3-kinase inhibitor (±)-wortmannin has been achieved through an intramolecular Heck reaction for the construction of an allylic quaternary carbon center and a diosphenol-Claisen rearrangement (see scheme). SEM = 2-(Tr
Synthetic studies on (+)-wortmannin. An asymmetric construction of an allylic quaternary carbon center by a Heck reaction
Honzawa,Mizutani,Shibasaki
, p. 311 - 314 (1999)
Treatment of (±)-4 with Pd(OAc)2, DPPP, TBAB and K2CO3 in toluene gave 16β in a highly stereoselective manner (17:1, 90%). Moreover, reaction of(±)-4 with Pd(OAc)2, (R)-Tol-BINAP and K2CO3 in toluene afforded 16β in 96% ee and in 20% yield.
