Synthetic studies on (+)-wortmannin. An asymmetric construction of an allylic quaternary carbon center by a Heck reaction

Article abstract of DOI:10.1016/S0040-4039(98)02298-9

Treatment of (±)-4 with Pd(OAc)₂, DPPP, TBAB and K₂CO₃ in toluene gave 16β in a highly stereoselective manner (17:1, 90%). Moreover, reaction of(±)-4 with Pd(OAc)₂, (R)-Tol-BINAP and K₂CO₃ in toluene afforded 16β in 96% ee and in 20% yield.