22109-30-4Relevant academic research and scientific papers
Diazotization of Aminopyridines in the Presence of Camphorsulfonic Acid. Synthesis and Some Properties of Pyridinyl Camphorsulfonates
Erin, K. D.,Filimonov, V. D.,Krasnokutskaya, E. A.,Sanzhiev, A. N.
, p. 922 - 929 (2021/07/22)
Abstract: Diazotization of 2-, 3-, and 4-aminopyridines in the presence of both racemic camphor-10-sulfonic acid and its pure enantiomers led to the formation of the corresponding pyridyl camphorsulfonates in moderate yields. Pyridyl camphorsulonates were
Antimycobacterial cycloartane derivatives from the roots of Trichilia welwistchii C. DC (Meliaceae)
Tsamo, Armelle Tontsa,Fodja Saah, Edwige P.,Langat, Moses K.,Mkounga, Pierre,Kamdem Waffo, Alain Fran?ois,Nkengfack, Augustin Ephrem
, p. 475 - 480 (2021/08/16)
Chemical investigation of the roots of Trichilia welwitschii yielded a cycloartane type terpenoid 28,29-bis-norcycloart-24-en-3β,4α,6α-triol (1), isolated as pure compound for the first time, three coumarins and three sterols. New cycloartane derivatives (1a) and (1b+1c) were obtained by hemi-synthetic reaction of compound 1. The structures of 1a-c were established by spectroscopic methods including 1D and 2D-NMR analysis, HR-EIMS, chemical transformations and by comparison of these data with those of related compounds. Evaluated for their antimycobacterial potential, compound 1 and 1b+1c were determined to show significant activities against Mycobacterium tuberculosis MIC values of 6.25 μg mL-1 while compound 1a displayed weak activity showing MIC > 100 μg mL-1. Compounds 2-4 displayed moderate activity with MIC values range from 12.5 to 50 μg mL-1.
ANTIDIABETIC BICYCLIC COMPOUNDS
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Page/Page column 196, (2016/04/04)
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Rhodium-catalysed nucleophilic ring opening reaction of 1- and 3-ethoxy-5,8-epoxy-5,8-dihydroisoquinolines
Kelebekli, Latif
, p. 304 - 308 (2013/07/27)
2-Ethoxy-3- and 5-chloropyridines were obtained from 2,3- and 2,5-dichloropyridine. Reaction of 2,3- and 2,5-dichloropyridines with tBuLi in the presence of furan gave 1- and 3-ethoxy-5,8-epoxy-5,8-dihydroisoquinolines. The rhodium-catalysed ring-opening
Compounds with medicinal effects due to interaction with the glucocorticoid receptor
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Page/Page column 16-17, (2010/11/27)
The invention provides for compounds having the structure according to the formula I
