221207-57-4

Upstream product

• 100-39-0 benzyl bromide 
• 182137-84-4 (1S,3R,4R)-3-Hydroxy-7-aza-bicyclo[2.2.1]heptane-1,7-dicarboxylic acid 7-benzyl ester 1-tert-butyl ester 

Downstream Products

• 221207-60-9 C₂₇H₃₂N₂O₄ 
• 221207-59-6 (1S,3R,4R)-3-Benzyloxy-1-((1R,2R,3R)-3-benzyloxycarbonylamino-1,2-dihydroxy-4-phenyl-butyl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester 
• 221207-61-0 C₄₁H₅₂N₄O₅Si 
• 221207-58-5 (1S,3R,4R)-3-Benzyloxy-1-formyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Tricylic ureas: A new class of HIV-1 protease inhibitors

A new class of tricyclic ureas containing a conformationally constrained proline was designed with the aid of molecular modeling. Efficient stereoselective intermolecular pinacol coupling represented the highlight of the synthesis. These rigid cyclic ureas are active towards HIV-1 protease, with 9 being the most potent compound (Ki = 9 nM) despite interacting with only three side chain binding pockets of HIV protease.