Bioorganic and Medicinal Chemistry Letters p. 3615 - 3620 (1998)
Update date:2022-07-31
Topics:
Han, Wei
Pelletier, Jeffrey C.
Hodge, C. Nicholas
A new class of tricyclic ureas containing a conformationally constrained proline was designed with the aid of molecular modeling. Efficient stereoselective intermolecular pinacol coupling represented the highlight of the synthesis. These rigid cyclic ureas are active towards HIV-1 protease, with 9 being the most potent compound (Ki = 9 nM) despite interacting with only three side chain binding pockets of HIV protease.
View MoreChangzhou Screw International Trading Co., Ltd.
Contact:13906149256,18001495888
Address:Jiangsu，Jintanqu
Anhui Jiatiansen Agrochemical Co.,Ltd
Contact:15366811918
Address:chemical industrial park,xiangyu town,dongzhi county,anhui,china
Nanjing Fayekong Chemcial Co.,Ltd(expird)
Contact:86-25-58813444
Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China
Contact:+86-28-88523492
Address:714rooms of Time Square, Pujiang County
Shandong Jincheng Zhonghua Bio-pharmaceutical Co.,Ltd
Contact:+86-533-5415882
Address:Zichuan Economic Development Zone,Zibo City,Shandong Province,China
Doi:10.1080/00397919908085778
(1999)Doi:10.1021/jm00302a013
(1969)Doi:10.1016/S0040-4020(98)01195-8
(1999)Doi:10.1016/S0040-4039(99)00042-8
(1999)Doi:10.1016/S0040-4020(00)00194-0
(2000)Doi:10.1021/acs.orglett.0c02894
(2020)
