951163-66-9

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxo-, anhydride with boric acid (H3BO3) (1:1), anhydride with acetic acid (1:2)
• CAS NO: 951163-66-9
• Molecular Formula: C18H17BFNO8
• Molecular Weight: 405.144
• Mol File: 951163-66-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxo-, anhydride with boric acid (H3BO3) (1:1), anhydride with acetic acid (1:2)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxo-, anhydride with boric acid (H3BO3) (1:1), anhydride with acetic acid (1:2)(951163-66-9)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-fluoro-1,4-dihydro-8-methoxy-4-oxo-, anhydride with boric acid (H3BO3) (1:1), anhydride with acetic acid (1:2)(951163-66-9)

Safety Data

• Hazardous Substances Data: 951163-66-9(Hazardous Substances Data)

Upstream product

• 221221-16-5 1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid 
• 4887-24-5 triacetoxyborane 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 1103242-32-5 boron trioxide 

Downstream Products

• 221221-16-5 1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid 

Relevant articles and documents

A method for preparing [...] chelate compound

The invention discloses a method for directly preparing a nemonoxacin chelate from nemonoxacin cyclization ester. According to the existing method, a reaction step is longer, and an amount of aftertreatment processes is larger, thus obviously prolonging the whole time of preparing nemonoxacin; and in addition, industrial production and environmental protection are not facilitated. The method comprises the following steps of: based on carboxylic acid anhydride or a mixed solvent of the carboxylic acid anhydride and carboxylic acid as a reaction solvent, adding boric acid or boric anhydride to carry out reaction; and adding the nemonoxacin cyclization ester into an obtained reaction solution to carry out chelation reaction, thus obtaining the nemonoxacin chelate. According to the preparation method, only one chelation reaction step exists, and a hydrolysis reaction process and complex aftertreatment operations thereof such as filtering and drying are saved, thus greatly shortening the whole time of preparing the nemonoxacin, and facilitating industrial production; and meanwhile, by avoiding the using of reagents such as concentrated hydrochloric acid and ethanol, the preparation method is economic and environment-friendly.

Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

The present invention is directed to malate salts of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid, and its polymorphs. The present invention is also directed to pharmaceutical compositions comprising the described salts and polymorphs.

Coupling process for preparing quinolone intermediates

Process for making 7-cycloamino-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acids. Borate ester compounds suitable for use in such process.