221221-11-0

Basic information

• Product Name: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE
• Synonyms: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE
• CAS NO: 221221-11-0
• Molecular Formula: C₈H₅ClF₂O₂
• Molecular Weight: 206.57
• Mol File: 221221-11-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE(221221-11-0)
• EPA Substance Registry System: 2,4-DIFLUORO-3-METHOXYBENZOYL CHLORIDE(221221-11-0)

Safety Data

• Hazardous Substances Data: 221221-11-0(Hazardous Substances Data)

Usage

General Description

2,4-difluoro-3-methoxybenzoyl chloride is a chemical compound with the molecular formula C8H6ClFO2. It is a benzoyl chloride derivative with two fluorine atoms and a methoxy group attached to the phenyl ring. 2,4-difluoro-3-methoxybenzoyl chloride is often used in organic synthesis as a versatile reagent for the introduction of the benzoyl group in various chemical reactions. It has also been utilized in the production of pharmaceuticals and agrochemicals. 2,4-difluoro-3-methoxybenzoyl chloride is a highly reactive compound that should be handled with care due to its potential to cause irritation, corrosion, and toxicity upon contact with skin, eyes, and mucous membranes.

Upstream product

• 437-82-1 1,3-difluoro-2-methoxybenzene 
• 28177-48-2 2,6-difluorophenol 
• 162101-25-9 2,6-difluorophenylboronic acid 
• 372-18-9 1,3-Difluorobenzene 
• 178974-97-5 2,4-difluoro-3-methoxy-benzoic acid 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 221221-13-2 ethyl 2-(2,4-difluoro-3-methoxybenzoyl)-3-cyclopropylaminoacrylate 
• 221221-15-4 ethyl cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolin-3-carboxylate 
• 221221-16-5 1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid 
• 1417560-72-5 C₂₀H₁₃F₂NO₂S 
• 1361253-26-0 2,4-difluoro-3-methoxy-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide 
• 1361252-94-9 2,4-difluoro-3-hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)benzamide 
• 922492-60-2 (Z)-ethyl 3-hydroxy-3-(2,4-difluoro-3-methoxyphenyl)acrylate 

Relevant articles and documents

1-cyclopropyl-4-oxo-7-fluoro-8-methoxy -1,4-dihydro-quinoline-3-carboxylic acid synthesizing method

The invention discloses a synthesis method of 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method comprises the following reaction steps: reacting m-difluorophenyl with an organolithium reagent, reacting an obtained aryllithium intermediate with borate, quenching to obtain 2,6-difluorophenylboronic acid and 2,6-difluorophenylborate, reacting 2,6-difluorophenol obtained through oxidation with a methylating reagent, reacting the obtained 2,6-difluorophenylmethyl ether with the organolithium reagent, reacting the obtained corresponding aryllithium intermediate with carbon dioxide, reacting the obtained product with an acylchlorinating reagent to obtain 2,4-difluoro-3-methoxy benzoyl chloride, and performing cyclization, hydrolysis and the like to obtain the 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method has the advantages as follows: raw materials are easy to obtain; the yield in each step is high; the atom economy is high; the synthesis method is suitable for industrial application.

8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS

The invention provides compound and salts of Formula (I) and (II), disclosed herein, which includes compounds of Formula (A) and Formula (B) such compounds possess useful antimicrobial activity. The variables R2, R3, R5, R

Antimicrobial quinolones, their compositions and uses

This invention relates to novel antimicrobial compounds of formula; wherein X, R1, R3, R5, R6, and R8 are defined in the claims, and to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically-acceptable salts, hydrates, and biohydrolyzable esters, amides and imides thereof, and to compositions and uses of such compounds. The invention also relates to compounds derived from these compounds having antimicrobial uses.