221298-75-5Relevant academic research and scientific papers
Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors
Liu, Kevin K.C.,Huang, Xiaojun,Bagrodia, Shubha,Chen, Jeffrey H.,Greasley, Samantha,Cheng, Hengmiao,Sun, Shaoxian,Knighton, Dan,Rodgers, Caroline,Rafidi, Kristina,Zou, Aihua,Xiao, Jiezhan,Yan, Shengyong
scheme or table, p. 1270 - 1274 (2011/04/16)
Intra-molecular hydrogen bonding was introduced to the quinazoline motif to form a pseudo ring (intra-molecular H-bond scaffold, iMHBS) to mimic our previous published core structures, pyrido[2.3-D]pyrimidin-7-one and pteridinone, as PI3K/mTOR dual inhibitors. This design results in potent PI3K/mTOR dual inhibitors and the purposed intra-molecular hydrogen bonding structure is well supported by co-crystal structure in PI3Kγ enzyme. In addition, a novel synthetic route was developed for these analogs.
Quinoline and quinazoline derivatives having corticotropin releasing factor (CRF) antagonist activity
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Page column 10, (2010/02/05)
The present invention relates to novel compounds, to a method for the preparation of these novel compounds, to pharmaceutical compositions containing one or more of these compounds as an active component and to methods of using these in the treatment of s
