104670-74-8

Basic information

• Product Name: Benzoic acid, 2-amino-3-bromo-, methyl ester
• Synonyms: Benzoic acid, 2-amino-3-bromo-, methyl ester;Methyl 2-aMino-3-broMobenzoate;3-Bromoanthranilic acid methyl ester;Ethyl 3-bromo-2-aminobenzoate;2-Amino-3-Bromo-, Methyl Ester
• CAS NO: 104670-74-8
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.05862
• EINECS: 200-158-5
• Mol File: 104670-74-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 47-48℃
• Boiling Point: 287.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.578±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 0.13±0.10(Predicted)
• CAS DataBase Reference: Benzoic acid, 2-amino-3-bromo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-amino-3-bromo-, methyl ester(104670-74-8)
• EPA Substance Registry System: Benzoic acid, 2-amino-3-bromo-, methyl ester(104670-74-8)

Safety Data

• Hazardous Substances Data: 104670-74-8(Hazardous Substances Data)

Usage

General Description

Benzoic acid, 2-amino-3-bromo-, methyl ester, also known as methyl 3-bromo-2-aminobenzoate, is a chemical compound with the molecular formula C8H8BrNO2. Benzoic acid, 2-amino-3-bromo-, methyl ester belongs to the family of benzoic acids and its derivatives, specifically the Benzoic acid esters. Typically presented as a colorless to light yellow liquid, it has applications in several fields. It has potential uses in the pharmaceutical industry for its antimicrobial activities. As an organic compound, it's also relevant in research and development contexts such as organic synthesis and material science. Kuraray and Sigma Aldrich are among the notable suppliers of this compound. It's important to handle this chemical with care due to its potential health hazards.

InChI:InChI=1S/C8H8BrNO2/c1-12-8(11)5-3-2-4-6(9)7(5)10/h2-4H,10H2,1H3

Upstream product

• 20780-74-9 7-bromoisatin 
• 134-20-3 2-carbomethoxyaniline 
• 101080-38-0 N-(2-bromo-phenyl)-2-[(E)-hydroxyimino]acetamine 
• 20776-51-6 2-amino-3-bromo benzoic acid 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 615-36-1 2-bromoaniline 
• 186581-53-3 diazomethane 

Downstream Products

• 304853-89-2 2-(2-amino-5-bromophenyl)-propan-2-ol 
• 873330-62-2 2-amino-3-phenylethynylbenzoic acid methyl ester 
• 1269467-96-0 methyl 2-amino-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 1269467-18-6 methyl 4-(3-ethynylphenylamino)thieno[3,2-c]quinoline-6-carboxylate 
• 1269467-92-6 N-(3-ethynylphenyl)-6-(1,3,4-oxadiazol-2-yl)thieno[3,2-c]quinolin-4-amine 
• 1269466-03-6 C₁₉H₁₃ClN₂O₂S 
• 1269466-05-8 4-(2-chlorophenylamino)thieno[3,2-c]quinoline-6-carboxylic acid 
• 1269466-06-9 4-(2-chlorophenylamino)thieno[3,2-c]quinoline-6-carboxamide 
• 1269464-21-2 N-(2-chlorophenyl)-6-(4H-1,2,4-triazol-3-yl)thieno[3.2-c]quinolin-4-amine 
• 1269464-20-1 N-(2-fluorophenyl)-6-(4H-1,2,4-triazol-3-yl)thieno[3,2-c]quinolin-4-aniline 
• 221298-75-5 2-methyl-4-chloro-8-bromo-quinazoline 
• 1268520-96-2 C₁₀H₉N₃O₂ 
• 20776-51-6 2-amino-3-bromo benzoic acid 
• 71478-56-3 8-bromo-2-methyl-4H-benzo[d][1,3]oxazin-4-one 

Relevant articles and documents

Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein

Niemann-Pick disease type C is a fatal, progressive neurodegenerative disease mostly caused by mutations in Nieamnn-Pick type C1 (NPC1), a late endosomal membrane protein that is essential for intracellular cholesterol transport. The most prevalent mutation, I1061T (Ile to Thr), interferes with the protein folding process. Consequently, mutated but intrinsically functional NPC1 proteins are prematurely degraded via proteasome, leading to loss of NPC1 function. Previously, we reported sterol derivatives as pharmacological chaperones for NPC1, and showed that these derivatives can normalize folding-defective phenotypes of I1061T NPC1 mutant by directly binding to, and stabilizing, the protein. Here, we report a series of compounds containing a phenanthridin-6-one scaffold as the first class of non-steroidal pharmacological chaperones for NPC1. We also examined their structure-activity relationships.

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

HERBICIDAL CINNOLINIUM COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.