221352-46-1

Usage

Uses

Used in Pharmaceutical Industry:
1,3-DIHYDRO-ISOINDOLE-1,2-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER is used as a key intermediate compound for the synthesis of various organic compounds with antiviral properties. Its role in the development of these compounds is crucial, as it aids in the creation of biaryls, arylheteroaryls, heteroaryls, and biarylacetylenes that are end-capped with amino acid or peptide derivatives, enhancing their antiviral effectiveness.
Used in Antiviral Research and Development:
In the field of antiviral research and development, 1,3-DIHYDRO-ISOINDOLE-1,2-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER serves as a valuable building block for designing and creating novel antiviral agents. Its chemical properties allow for the modification and functionalization of the synthesized compounds, leading to the development of more potent and targeted antiviral drugs.
Used in Drug Delivery Systems:
Similar to gallotannin, 1,3-DIHYDRO-ISOINDOLE-1,2-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER can also be employed in the development of innovative drug delivery systems. These systems can help improve the bioavailability, delivery, and therapeutic outcomes of the synthesized antiviral agents, making them more effective against viral infections.

InChI:InChI=1/C14H17NO4/c1-14(2,3)19-13(18)15-8-9-6-4-5-7-10(9)11(15)12(16)17/h4-7,11H,8H2,1-3H3,(H,16,17)

Upstream product

• 1367468-00-5 tert-butyl (+/-)-1-cyano-1,3-dihydro-2H-isoindole-2-carboxylate 
• 1367467-98-8 tert-butyl (+/-)-1-methoxy-1,3-dihydro-2H-isoindole-2-carboxylate 
• 1367467-96-6 tert-butyl (+/-)-1-hydroxy-1,3-dihydro-2H-isoindole-2-carboxylate 
• 124-38-9 carbon dioxide 
• 1359987-44-2 O-tert-butyl 1-(tributylstannyl)isoindoline-2-carboxylate 
• 444583-12-4 1-methoxycarbonylmethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 

Downstream Products

• 444607-92-5 2-(tert-butyl) 1-methyl isoindoline-1,2-dicarboxylate 
• 66938-02-1 L-1,3-dihydro-isoindol-1-carboxylic acid 
• 96016-96-5 1,3-Dihydro-2H-isoindole-1-carboxylic Acid Hydrochloride 
• 936828-28-3 1-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 1179149-61-1 C₁₀H₁₁NO₂ 
• 1255936-31-2 C₂₂H₂₃BrN₂O₄ 
• 96325-09-6 2-benzyl 1-methyl (+/-)-1,3-dihydro-2H-isoindole-1,2-dicarboxylate 
• 96325-10-9 (+/-)-2-[(benzyloxy)carbonyl]-1,3-dihydro-2H-isoindole-1-carboxylic acid 
• 1367468-10-7 (R)-2-benzyl 1-methyl 1,3-dihydro-2H-isoindole-1,2-dicarboxylate 
• 1367468-16-3 C₂₀H₁₈F₃NO₄ 
• 1367468-14-1 C₂₀H₁₈F₃NO₄ 
• 781597-60-2 methyl (S)-1,3-dihydro-2H-isoindole-1-carboxylate 
• 1367468-12-9 methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate 
• 111605-85-7 methyl (+/-)-1,3-dihydro-2H-isoindole-1-carboxylate 

Relevant academic research and scientific papers

Dynamic kinetic resolution of 1,3-dihydro-2 h-isoindole-1-carboxylic acid methyl ester: Asymmetric transformations toward isoindoline carbamates

Asymmetric syntheses of isoindoline carbamates have been successfully achieved through enzyme-mediated dynamic kinetic resolution processes and without requirement of metal or acid-base catalyst for the substrate racemization. Optically active carbamates

Synthesis of arylglycine and mandelic acid derivatives through carboxylations of α-amido and α-acetoxy stannanes with carbon dioxide

Incorporation reactions of carbon dioxide (CO2) with N-Boc-α-amido and α-acetoxy stannanes were developed using CsF as a mild tin activator. Monoprotected α-amido stannanes could be used, and the corresponding arylglycine derivatives were obtained in moderate-to-high yields under 1 MPa (10 atm) of CO2 pressure. α-Acetoxy stannanes also underwent carboxylation to afford mandelic acid derivatives in excellent yields under ambient CO2 pressure. Both transformations enabled the synthesis of α-tertiary and α-quaternary carboxylic acid derivatives. In addition, the chirality of (S)-N-tert-butylsulfonyl-α- amido stannanes was transferred with up to 90% inversion of configuration at 100 °C.

Piperazine- and piperidine-derivatives as melanocortin receptor agonists

The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.