111605-85-7

Upstream product

• 67-56-1 methanol 
• 96016-96-5 1,3-Dihydro-2H-isoindole-1-carboxylic Acid Hydrochloride 
• 1367467-96-6 tert-butyl (+/-)-1-hydroxy-1,3-dihydro-2H-isoindole-2-carboxylate 
• 1367467-98-8 tert-butyl (+/-)-1-methoxy-1,3-dihydro-2H-isoindole-2-carboxylate 
• 1367468-00-5 tert-butyl (+/-)-1-cyano-1,3-dihydro-2H-isoindole-2-carboxylate 
• 221352-46-1 2-(tert-butoxycarbonyl)isoindoline-1-carboxylic acid 
• 480-91-1 oxisoindole 
• 1367468-08-3 2-allyl 1-methyl (R)-1,3-dihydro-2H-isoindole-1,2-dicarboxylate 
• 1367468-10-7 (R)-2-benzyl 1-methyl 1,3-dihydro-2H-isoindole-1,2-dicarboxylate 
• 444607-92-5 2-(tert-butyl) 1-methyl isoindoline-1,2-dicarboxylate 

Downstream Products

• 781597-60-2 methyl (S)-1,3-dihydro-2H-isoindole-1-carboxylate 
• 1367468-12-9 methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate 
• 914298-27-4 2-(5-chloro-2,4-bis-methoxymethoxybenzoyl)-2,3-dihydro-1H-isoindole-1-carboxylic acid 
• 444607-92-5 2-(tert-butyl) 1-methyl isoindoline-1,2-dicarboxylate 

Relevant academic research and scientific papers

Stereospecific ring-expanding skeletal rearrangement of isoindoline to tetrahydroisoquinoline via a sequential aziridine ring formation/opening

A stereospecific skeletal rearrangement of isoindoline to tetrahydroisoquinoline was developed under Appel reaction conditions using a combination of PPh3 and CCl4. This reaction involves a sequential ring formation/opening of a labile aziridine and enables the construction of a quaternary carbon center, offering a highly useful method for accessing 3,3,4-trisubstituted tetrahydroisoquinolines.

Dynamic kinetic resolution of 1,3-dihydro-2 h-isoindole-1-carboxylic acid methyl ester: Asymmetric transformations toward isoindoline carbamates

Asymmetric syntheses of isoindoline carbamates have been successfully achieved through enzyme-mediated dynamic kinetic resolution processes and without requirement of metal or acid-base catalyst for the substrate racemization. Optically active carbamates

AMIDE RESORCINOL COMPOUNDS

The present invention is directed to amide resorcinol compounds and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.

AMIDE RESORCINOL COMPOUNDS

The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.