221353-38-4Relevant academic research and scientific papers
Efficient synthesis of o-alkynyl-N-pivaloylanilines from o-acyl-N-pivaloylanilines and lithium trimethylsilyldiazomethane
Hari, Yoshiyuki,Kanie, Tomoki,Aoyama, Toyohiko
, p. 1137 - 1139 (2006)
Reaction of o-acyl-N-pivaloylanilines with lithium trimethylsilyldiazomethane efficiently gave the corresponding o-alkynyl-N-pivaloylanilines via alkylidenecarbene intermediates.
Copper-catalyzed oxidative ring closure and carboarylation of 2-ethynylanilides
Sinai, Adam,Meszaros, Adam,Gati, Tamas,Kudar, Veronika,Pallo, Anna,Novak, Zoltan
, p. 5654 - 5657 (2013/12/04)
A new copper-catalyzed oxidative ring closure of ethynyl anilides with diaryliodonium salts was developed for the highly modular construction of benzoxazines bearing a fully substituted exo double bond. The oxidative transformation includes an unusual 6-exo-dig cyclization step with the formation of C-O and C-C bonds.
Palladium-catalyzed highly regio-and stereoselective synthesis of 4-alkylidene-4 H -3,1-benzoxazines from N -Acyl-o -alkynylanilines
Saito, Takao,Ogawa, Shohei,Takei, Naoya,Kutsumura, Noriki,Otani, Takashi
, p. 1098 - 1101 (2011/04/26)
The highly regio-and stereoselective 6-exo-dig mode cyclization of N-acyl-o-alkynylanilines producing 4-alkylidene-3,1-benzoxazines occurred unpredictably by use of a proper catalyst [Pd(OAc)2] and an effective additive (acetic acid) under suit
Convenient synthesis of 2-substituted indoles from 2-ethynylanilines with tetrabutylammonium fluoride
Yasuhara, Akito,Kanamori, Yuichi,Kaneko, Masashi,Numata, Atsushi,Kondo, Yoshinori,Sakamoto, Takao
, p. 529 - 534 (2007/10/03)
The cyclization reaction of various 2-ethynylanilines, which were easily synthesized from 2-haloanilines by the palladium-catalyzed reaction with terminal alkynes, with tetrabutylammonium fluoride (TBAF) to yield 2-substituted indoles proceeded at refluxing or room temperature in THF in excellent yields without affecting the bromo, chloro, cyano, ethoxycarbonyl, and ethynyl groups.
