28586-43-8Relevant academic research and scientific papers
The reaction of o-amino aryl carboxylic acids with Grignard reagents. The unusual effect of the N-protecting group on aryl ketone formation
Zhang, Puwen,Terefenko, Eugene A.,Slavin, Joseph
, p. 2097 - 2099 (2001)
The addition of Grignard reagents to the o-amino aryl carboxylic acids without any additive forms the tertiary carbinol as a major product. Unexpectedly, the aryl ketones are formed as the only isolated product if o-amino moiety of anthranilic acids is protected with Boc, trifluoroacetyl, and pivaloyl protecting groups.
Bioactive 3,4,5-substituted benzodiazepine 2-one drug molecules and preparation method thereof
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, (2018/04/26)
The invention discloses bioactive 3,4,5-substituted benzodiazepine 2-one drug molecules and a preparation method thereof and belongs to the technical field of drug synthesis. The technical scheme is characterized in that the structure of the compounds is shown in the description, wherein R1 is methyl, pyridyl, phenyl or isopropyl; R1 and R2 are selected from methyl, ethyl or phenyl independently respectively. Compared with the prior art, the compounds and the preparation method have the following beneficial effects: the synthesis method is simple, the molecular structure is novel, and the compounds have an inhibition effect on the leukemia cell line K562 and the breast cancer cell MCF-7 and are expected to be further popularized and applied.
Merging Photoredox with Palladium Catalysis: Decarboxylative ortho-Acylation of Acetanilides with α-Oxocarboxylic Acids under Mild Reaction Conditions
Zhou, Chao,Li, Pinhua,Zhu, Xianjin,Wang, Lei
supporting information, p. 6198 - 6201 (2016/01/09)
A room temperature decarboxylative ortho-acylation of acetanilides with α-oxocarboxylic acids has been developed via a novel Eosin Y with Pd dual catalytic system. This dual catalytic reaction shows a broad substrate scope and good functional group tolera
Palladium-catalyzed oxidative C-H bond acylation of acetanilides with benzylic alcohols
Yuan, Yu,Chen, Duanteng,Wang, Xiaowei
, p. 3373 - 3379 (2012/02/03)
An efficient and clean method to construct C-C bonds has been developed via the acylation reaction of acetanilides with benzylic alcohols using tert-butyl hydroperoxide (TBHP) as oxidant catalyzed by palladium acetate in the presence of triflic acid (TfOH). The acylation reactions exhibit excellent reactivities, and up to 95% yield of the corresponding aryl ketone could be obtained under the optimal conditions. Copyright
Titanium-Induced Syntheses of Furans, Benzofurans and Indoles
Fuerstner, Alois,Jumbam, Denis N.
, p. 5991 - 6010 (2007/10/02)
Highly reactive titanium on graphite as the reagent of choice promotes intramolecular McMurry type reactions of acyloxy- and acylamido carbonyl compounds affording furans, benzofurans and indoles in good to excellent yields.A variety of reducible groups in the substrates is tolerated (e.g. -F, -Cl, -Br, -I, -CF3, -OMe, -CN, -thiophenyl, -COOR, -CONR2) and strained products such as 11h can be obtained, the X-ray analysis of which is reported.The experimental results indicate the possible formation of dianions from the aromatic aldehydes or ketones as reactive intermediates which attack the ester or amide functions in their proximity, rather than a radical path via ketyls.
