5333-74-4

Usage

InChI:InChI=1/C8H14O3/c1-5-11-7(10)6(9)8(2,3)4/h5H2,1-4H3

Upstream product

• 109845-24-1 3,3-dimethyl-2-oxo-butyraldehyde diethylacetal 
• 201230-82-2 carbon monoxide 
• 594-19-4 tert.-butyl lithium 
• 105-58-8 Diethyl carbonate 
• 74-96-4 ethyl bromide 
• 815-17-8 trimethylpyruvic acid 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 677-22-5 tert-butylmagnesium chloride 
• 95-92-1 oxalic acid diethyl ester 
• 507-20-0 tertiary butyl chloride 
• 90054-58-3 1,2-diethoxy-1,2-bis(trimethylsilyloxy)ethylene 
• 64-17-5 ethanol 

Downstream Products

• 815-17-8 trimethylpyruvic acid 
• 107-46-0 Hexamethyldisiloxane 
• 122889-18-3 3,3-Dimethyl-2-[(Z)-trimethylsilanyl-imino]-butyric acid ethyl ester 
• 31612-63-2 (R)-3,3-dimethylbutane-1,2-diol 
• 31612-63-2 (2S)-3,3-dimethylbutane-1,2-diol 
• 22146-57-2 (2R)-3,3-Dimethyl-2-hydroxybutyric acid 
• 69610-03-3 Ethyl tert-leucinate 
• 69813-12-3 2-Benzylsulfanyl-3,3-dimethyl-butyric acid ethyl ester 
• 1003322-81-3 C₁₅H₂₀ClFN₂O₂ 
• 1228444-55-0 (R,R)-ethyl 2-hydroxy-3,3-dimethyl-2-(5-oxo-2,5-dihydrofuran-2-yl)butanoate 
• 1258611-34-5 C₁₅H₂₀N₂O₃ 
• 1453490-91-9 C₁₅H₂₁NO₄S 

Relevant academic research and scientific papers

Di-tert-butyl thiopyridazine boratrane complexes of Co, Ni and Cu

The thiopyridazine based scorpionate ligand sodium tris(3,5-di-tert-butyl-6-thioxopyridazin-1(6H)-yl)hydroborate (NaTntBu,tBu) with two tert-butyl substituents in ortho- and para-position of the thio group was synthesized and fully characterized. Corresponding metallaboratrane complexes [M{B(PntBu,tBu)3}Cl] (M = Co, Ni, Cu) as well as [M{B(PnMe,tBu)3}Cl] (M = Co, Ni) were prepared in good yields. All complexes were characterized by spectroscopic means as well as by single crystal X-ray diffraction studies exhibiting short metal boron bonds (between 2.0186(17) ? and 2.069(3) ?) compared to previously reported boratranes. The two tert-butyl groups attached to the heterocycle significantly increases the solubility of NaTntBu,tBuand the derived metal complexes in apolar solvents compared to the system bearing the smaller substituents. The higher steric demand of the tert-butyl versus methyl group enhances the distortion from trigonal bipyramidal towards square pyramidal which effects the electronic situation within the complexes evidenced by the elongated metal chlorine bond trans to boron.

Diastereo- and Enantioselective Synthesis of Fluorine Motifs with Two Contiguous Stereogenic Centers

The synthesis of chiral fluorine containing motifs, in particular, chiral fluorine molecules with two contiguous stereogenic centers, has attracted much interest in research due to the limited number of methods available for their preparation. Herein, we report an atom-economical and highly stereoselective synthesis of chiral fluorine molecules with two contiguous stereogenic centers via azabicyclo iridium-oxazoline-phosphine-catalyzed hydrogenation of readily available vinyl fluorides. Various aromatic, aliphatic, and heterocyclic systems with a variety of functional groups were found to be compatible with the reaction and provide the highly desirable product as single diastereomers with excellent enantioselectivities.

N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS

The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example

Stereoselective synthesis of a potent thrombin inhibitor by a novel P2-P3 lactone ring opening

The concise synthesis of a potent thrombin inhibitor was accomplished by a mild lactone aminolysis between an orthogonally protected bis-benzylic amine and a diastereomerically pure lactone. The lactone was synthesized by the condensation of L-proline met

N-heterocyclic bicyclic lactone compounds

Novel N-heterocyclic bicyclic lactone compounds of formula I and its novel hydroxyamide precursors of formula IV, are synthesized by coupling a hydroxy acid of formula II with an ester of formula III or a pharmaceutically acceptable salt thereof, in the presence of a peptide coupling reagent to produce a hydroxyamide of formula IV, and cyclizing the hydroxyamide of formula IV to produce compounds of formula 1.

Synthesis of α-Diketones by Direct, Low-temperature, in Situ Nucleophilic Acylation of Esters by Acyllithium Reagents

Addition of n-, sec-, or tert-butyllithium to a CO-saturated solution of an ester, R'CO2R'' in a solvent system of 4:4:1 (by volume) THF/Et2O/pentane at -110 deg C (or at -135 deg C in 3:1 (by volume) Me2O/THF), followed by hydrolysis with saturated aqueous NH4Cl, results in the formation of α-diketones, BuC(O)C(O)R', yellow liquids, in good yield.Similar reactions with diethyl succinate gave in one instance both t-BuC(O)C(O)CH2CH2CO2Et and t-BuC(O)C(O)CH2CH2C(O)C(O)Bu-t.The monoacylation product of dimethyl oxalate, t-BuC(O)C(O)CO2Me, readily formed a crystalline hydrate, t-BuC(O)C(OH)2CO2Me.

A MILD AND VARIABLE SYNTHESIS OF α-KETOESTERS

The ZnCl2 promoted addition of 1,2-diethoxy-1,2-disilyloxyethylene 1 with electrophiles such as aldehydes, ketones, α,β-unsaturated ketones or tertiary alkyl halides allows for a simple synthesis of α-ketoesters.