221548-37-4Relevant academic research and scientific papers
Catalyst free approach to benzimidazoles using air as the oxidant at room temperature
Zhang, Chun,Zhang, Liangren,Jiao, Ning
supporting information, p. 3273 - 3276 (2013/01/16)
A green and practical method to construct benzimidazoles, which are ubiquitous structural units in a number of biologically active compounds, has been developed. The catalyst and additive free conditions, using air as oxidant and the mild conditions make
Synthesis of condensed heterocycles via cyclopropylimine rearrangement of cyclopropylazoles
Tomilov, Yury V.,Platonov, Dmitry N.,Frumkin, Aleksandr E.,Lipilin, Dmitry L.,Salikov, Rinat F.
supporting information; experimental part, p. 5120 - 5123 (2010/11/16)
Thermal cyclopropylimine rearrangement of cyclopropylazoles into condensed heterocycles and factors affecting the regioselectivity and conversion are reported. A method of conducting the reaction in the absence of solvents is developed. A series of 2-cyclopropylazoles, including novel examples, is synthesized and their transformations into the corresponding condensed heterocyclic compounds (2,3-dihydro-1H-pyrroles and 6,7-dihydro-5H-pyrrolo[2,1- b]thiazolium salts) are studied.
Copper-catalyzed synthesis of benzimidazoles via cascade reactions of o-haloacetanilide derivatives with amidine hydrochlorides
Yang, Daoshan,Fu, Hua,Hu, Liming,Jiang, Yuyang,Zhao, Yufen
, p. 7841 - 7844 (2008/12/22)
(Chemical Equation Presented) We have developed an efficient method for the synthesis of benzimidazoles via cascade reactions of o-haloacetoanilide derivatives with amidine hydrochlorides. The protocol uses 10 mol % CuBr as the catalyst, CS2CO
