10252-94-5

Basic information

• Product Name: 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methyl-(7CI,8CI,9CI)
• Synonyms: 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methyl-(7CI,8CI,9CI);6-methyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole
• CAS NO: 10252-94-5
• Molecular Formula: C11H12N2
• Molecular Weight: 172.22638
• Product Categories: BENZIMIDAZOLE
• Mol File: 10252-94-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 144-145 °C
• Boiling Point: 355.7±11.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• PKA: 6.18±0.20(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methyl-(7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methyl-(7CI,8CI,9CI)(10252-94-5)
• EPA Substance Registry System: 1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-6-methyl-(7CI,8CI,9CI)(10252-94-5)

Safety Data

• Hazardous Substances Data: 10252-94-5(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic (consists of a benzimidazole ring fused with a pyrrole ring)

Form

Dihydro (contains two hydrogen atoms)

Substitution

6-methyl (a methyl group attached to the sixth carbon atom)

Usage

Building block for the synthesis of various biologically active compounds in the pharmaceutical industry, as well as in the production of agrochemicals and other fine chemicals.

Upstream product

• 221548-37-4 2-cyclopropyl-5-methyl-1H-benzimidazole 
• 96-48-0 4-butanolide 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 91429-70-8 5-methyl-2-(pyrrolidin-1-yl)aniline 
• 616-45-5 2-pyrrolidinon 
• 5367-26-0 3-chloro-2-nitrotoluene 
• 89-60-1 1-chloro-4-methyl-2-nitro-benzene 

Relevant articles and documents

Greener synthesis using hydrogen peroxide in ethyl acetate of alicyclic ring-fused benzimidazoles and anti-tumour benzimidazolequinones

Environmentally-friendly and cost effective hydrogen peroxide in ethyl acetate was used to prepare in high yields pyrrolo[1,2-a]benzimidazoles from commercial o-(pyrrolidin-1-yl)anilines without the requirement for organic-aqueous extraction and chromatography. Six, seven and eight membered ring-fused analogues were similarly obtained in high yields with methanesulfonic acid required for the pyrido[1,2-a]benzimidazole. Anti-tumour benzimidazolequinone derivatives were obtained in high yield via the cyclization of 3,6-dimethoxy-2-(cycloamino)anilines.

Synthesis of condensed heterocycles via cyclopropylimine rearrangement of cyclopropylazoles

Thermal cyclopropylimine rearrangement of cyclopropylazoles into condensed heterocycles and factors affecting the regioselectivity and conversion are reported. A method of conducting the reaction in the absence of solvents is developed. A series of 2-cyclopropylazoles, including novel examples, is synthesized and their transformations into the corresponding condensed heterocyclic compounds (2,3-dihydro-1H-pyrroles and 6,7-dihydro-5H-pyrrolo[2,1- b]thiazolium salts) are studied.

Methine dyes

The invention relates to a new class of pyrrolobenzimidazole, benzimidazoloisoquinoline and dipyrodinobenzodiimidazole in cyanine sensitizing dyes derived therefrom and their use in silver halide emulsions, and to methods for preparation of such new dyes.