2217-08-5 Usage
Uses
Used in Pharmaceutical Industry:
5,5-DI-N-PROPYLBARBITURIC ACID is used as a sedative-hypnotic agent for its ability to induce calming effects on the central nervous system, primarily for the treatment of insomnia and as a pre-anesthetic medication. Its use in this capacity is due to its action on enhancing GABA neurotransmission, which helps to promote relaxation and sleep.
Used in Research and Development:
In the field of pharmaceutical research and development, 5,5-DI-N-PROPYLBARBITURIC ACID serves as an important compound for studying the pharmacology of barbiturates. Understanding its mechanisms and effects contributes to the advancement of safer and more effective sedative and hypnotic medications.
Used in Substance Abuse Prevention and Education:
Given its potential for dependence and abuse, 5,5-DI-N-PROPYLBARBITURIC ACID is also utilized in substance abuse prevention and education programs. It serves as a case study for understanding the risks associated with certain classes of drugs and the development of strategies to mitigate these risks in medical practice.
Check Digit Verification of cas no
The CAS Registry Mumber 2217-08-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,1 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2217-08:
(6*2)+(5*2)+(4*1)+(3*7)+(2*0)+(1*8)=55
55 % 10 = 5
So 2217-08-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H16N2O3/c1-3-5-10(6-4-2)7(13)11-9(15)12-8(10)14/h3-6H2,1-2H3,(H2,11,12,13,14,15)
2217-08-5Relevant articles and documents
Substituent effects on partition coefficients of barbituric acids
Wong,McKeown
, p. 926 - 932 (2007/10/02)
Precise partition coefficients in 1-octanol-water at 25°C were determined for three 2-thiobarbituric acids and 14 barbituric acids with a wider range of substituents. The experimental log P values (log P(exp)) of barbituric acids were correlated with the carbon number and the branching effect of the C5 substituent(s) by linear regression analysis. The carbon number term makes a major contribution to the partition coefficients. The contribution of the polar effect of the C5 substituents was insignificant in contrast to a previous report. Hydrophobic constants (π) were determined for allyl, phenyl, and chloro-substituents, and these emperical π values gave much closer predicted calculated log P (log P(calc)) values when applied to the reported log P(exp) values.
Synthesis and reactions of some N-mono- and N,N'-bis-salicyloyl derivatives of barbituric acid
Sladowska
, p. 447 - 456 (2007/10/02)
N,N'-Bis-salicyloyl derivatives unlike the N-mono-salicyloyl derivatives of barbituric acid underwent thermal decomposition. The decomposition products depend on the size of the substituents in the position 5. When one of them is phenyl, salicyloyl radicals are split off without cleavage of the barbituric ring.
