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6065-63-0 Usage

Chemical Properties

Light Yellow Oil

Uses

Diethyl dipropylmalonate is used in the preparation of Valporic Acid (V094750).

Check Digit Verification of cas no

The CAS Registry Mumber 6065-63-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,6 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6065-63:
(6*6)+(5*0)+(4*6)+(3*5)+(2*6)+(1*3)=90
90 % 10 = 0
So 6065-63-0 is a valid CAS Registry Number.
InChI:InChI=1/C13H24O4/c1-5-9-13(10-6-2,11(14)16-7-3)12(15)17-8-4/h5-10H2,1-4H3

6065-63-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • Detail
  • Alfa Aesar

  • (B25062)  Diethyl di-n-propylmalonate, 97%   

  • 6065-63-0

  • 25g

  • 551.0CNY

  • Detail
  • Alfa Aesar

  • (B25062)  Diethyl di-n-propylmalonate, 97%   

  • 6065-63-0

  • 100g

  • 1111.0CNY

  • Detail
  • Alfa Aesar

  • (B25062)  Diethyl di-n-propylmalonate, 97%   

  • 6065-63-0

  • 500g

  • 4298.0CNY

  • Detail

6065-63-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Diethyl dipropylmalonate

1.2 Other means of identification

Product number -
Other names diethyl 2,2-dipropylpropanedioate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6065-63-0 SDS

6065-63-0Synthetic route

diallylmalonic acid diethyl ester
3195-24-2

diallylmalonic acid diethyl ester

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

Conditions
ConditionsYield
With 6C53H32O8(4-)*13Zr(4+)*18O(2-)*8Co(2+)*8H(1-); hydrogen In tetrahydrofuran at 23℃; under 30003 Torr; for 36h; Catalytic behavior; Mechanism; Reagent/catalyst;100%
With sodium tetrahydroborate; ruthenium trichloride In tetrahydrofuran; water at 20℃; for 1h;93%
With 6C53H32O8(4-)*13Zr(4+)*18O(2-)*8Co(2+)*8Cl(1-); hydrogen; sodium triethylborohydride In tetrahydrofuran at 23℃; under 30402 Torr; for 36h; Catalytic behavior; Time; Glovebox; Inert atmosphere;100 %Spectr.
With fac-[Mn(1,2-bis(di-isopropylphosphino)ethane)(CO)3(CH2CH2CH3)]; hydrogen In diethyl ether at 25℃; under 37503.8 Torr; for 18h;75 %Chromat.
With hydrogen In water at 60℃; under 22502.3 Torr; for 18h; Autoclave; Green chemistry;
diethyl 2-(3-iodopropyl)-2-propylmalonate
1439866-82-6

diethyl 2-(3-iodopropyl)-2-propylmalonate

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

Conditions
ConditionsYield
With [Ir(2-phenylpyridine)-2-(4,4’-di-tert-butyl-2,2’-bipyridine)]PF6; N-ethyl-N,N-diisopropylamine In acetonitrile at 25℃; for 5h; Irradiation;88%
propyl bromide
106-94-5

propyl bromide

diethyl propylmalonate
2163-48-6

diethyl propylmalonate

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 10h; Heating;83%
1-iodo-propane
107-08-4

1-iodo-propane

diethyl propylmalonate
2163-48-6

diethyl propylmalonate

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

Conditions
ConditionsYield
With caesium carbonate In butanone at 70℃; for 15h;70%
propyl bromide
106-94-5

propyl bromide

diethyl malonate
105-53-3

diethyl malonate

A

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

B

n-propylmalonic acid
616-62-6

n-propylmalonic acid

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride for 16h;A 48%
B 41%
1-iodo-propane
107-08-4

1-iodo-propane

diethyl malonate
105-53-3

diethyl malonate

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

Conditions
ConditionsYield
With zinc
1-iodo-propane
107-08-4

1-iodo-propane

diethyl malonate
105-53-3

diethyl malonate

A

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

B

diethyl propylmalonate
2163-48-6

diethyl propylmalonate

Conditions
ConditionsYield
With zinc
1-iodo-propane
107-08-4

1-iodo-propane

diethyl malonate
105-53-3

diethyl malonate

A

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

B

diethyl propylmalonate
2163-48-6

diethyl propylmalonate

diethyl malonate
105-53-3

diethyl malonate

6-ethoxy-4-cyano-5-methyl-hex-2ξ-enoic acid ethyl ester

6-ethoxy-4-cyano-5-methyl-hex-2ξ-enoic acid ethyl ester

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / NaOEt / ethanol / 7 h / Heating
2: 83 percent / NaOEt / ethanol / 10 h / Heating
View Scheme
4,4-bis(ethoxycarbonyl)-1-hepten-6-yne
101268-55-7

4,4-bis(ethoxycarbonyl)-1-hepten-6-yne

A

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

B

diethyl cis-3,4-dimethylcyclopentane-1,1-dicarboxylate
1114376-78-1

diethyl cis-3,4-dimethylcyclopentane-1,1-dicarboxylate

diethyl (3R,4R)-3,4-dimethylcyclopentane-1,1-dicarboxylate

diethyl (3R,4R)-3,4-dimethylcyclopentane-1,1-dicarboxylate

Conditions
ConditionsYield
With (IPr2,6-(2,6-iPr2C6H3N=CMe)2C5H3N)Fe(N2)2; hydrogen In benzene at 23℃; under 3040.2 Torr; for 3h; Inert atmosphere; optical yield given as %de;A 25.9 %Chromat.
B n/a
C n/a
diethyl propylmalonate
2163-48-6

diethyl propylmalonate

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride; hydrogen / mineral oil; tetrahydrofuran / 12 h / 0 - 20 °C
2: [Ir(2-phenylpyridine)-2-(4,4’-di-tert-butyl-2,2’-bipyridine)]PF6; N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 25 °C / Irradiation
View Scheme
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

thiourea
17356-08-0

thiourea

5,5-di-n-propyl-2-thiobarbituric acid
99167-62-1

5,5-di-n-propyl-2-thiobarbituric acid

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 50℃; for 12h;96%
With sodium ethanolate
With ethanol; sodium ethanolate at 100℃;
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

2,2-di-n-propyl-1,3-propanediol
24765-54-6

2,2-di-n-propyl-1,3-propanediol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 2h;92%
With lithium aluminium tetrahydride; diethyl ether
With lithium aluminium tetrahydride In diethyl ether
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

urea
57-13-6

urea

5,5-dipropylbarbituric acid
2217-08-5

5,5-dipropylbarbituric acid

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 12h; Heating;23%
With sodium ethanolate at 100℃; im geschlossenen Gefaess;
With sodium ethanolate at 100℃; im geschlossenen Gefaess;
methyl magnesium iodide
917-64-6

methyl magnesium iodide

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

valproic acid
99-66-1

valproic acid

Conditions
ConditionsYield
und durch Behandeln des Reaktionprodukts mit Barytwasser, neben Aceton;
methyl magnesium iodide
917-64-6

methyl magnesium iodide

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

A

valproic acid
99-66-1

valproic acid

B

acetone
67-64-1

acetone

Conditions
ConditionsYield
Verseifung des Reaktionsproduktes;
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

benzamidine monohydrochloride
1670-14-0

benzamidine monohydrochloride

2-phenyl-5,5-dipropyl-1H-pyrimidine-4,6-dione

2-phenyl-5,5-dipropyl-1H-pyrimidine-4,6-dione

Conditions
ConditionsYield
With sodium ethanolate at 70℃;
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

methylmagnesium iodide

methylmagnesium iodide

A

valproic acid
99-66-1

valproic acid

B

acetone
67-64-1

acetone

Conditions
ConditionsYield
Verseifung des Reaktionsprodukts;
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

phenylhydrazine hydrochloride
59-88-1

phenylhydrazine hydrochloride

1-phenyl-4,4-dipropyl-pyrazolidine-3,5-dione

1-phenyl-4,4-dipropyl-pyrazolidine-3,5-dione

Conditions
ConditionsYield
With ethanol; sodium ethanolate at 160℃;
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

4,4-dipropyl-pyrazolidine-3,5-dione
342618-11-5

4,4-dipropyl-pyrazolidine-3,5-dione

Conditions
ConditionsYield
With hydrazine hydrochloride; sodium ethanolate
With sodium ethanolate; hydrazine hydrate
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

monoethyl α,α-dipropylmalonate
258264-00-5

monoethyl α,α-dipropylmalonate

Conditions
ConditionsYield
With potassium hydroxide Kaliumsalz entsteht;
With ethanol; sodium hydroxide at 20℃; for 12h;
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

3,3-dipropyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

3,3-dipropyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

Conditions
ConditionsYield
With sodium ethanolate
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

valproic acid
99-66-1

valproic acid

Conditions
ConditionsYield
(i) aq. KOH, (ii) (decarboxylation); Multistep reaction;
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

dimethyl 2,2-propylmalonamide
90728-92-0

dimethyl 2,2-propylmalonamide

Conditions
ConditionsYield
With sodium methylate; formamide In methanol Heating;
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

sodium ethanolate
141-52-6

sodium ethanolate

hydrazine hydrochloride

hydrazine hydrochloride

4,4-dipropyl-pyrazolidine-3,5-dione
342618-11-5

4,4-dipropyl-pyrazolidine-3,5-dione

Conditions
ConditionsYield
at 100 - 110℃;
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

ZnCl2

ZnCl2

A

ethene
74-85-1

ethene

B

ethyl 2-propylpentanoate
17022-31-0

ethyl 2-propylpentanoate

diethyl ether
60-29-7

diethyl ether

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

potassium

potassium

A

ethyl 2-propylpentanoate
17022-31-0

ethyl 2-propylpentanoate

B

monoethyl α,α-dipropylmalonate
258264-00-5

monoethyl α,α-dipropylmalonate

C

CO

CO

diethyl ether
60-29-7

diethyl ether

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

sodium

sodium

A

ethyl 2-propylpentanoate
17022-31-0

ethyl 2-propylpentanoate

B

monoethyl α,α-dipropylmalonate
258264-00-5

monoethyl α,α-dipropylmalonate

C

CO

CO

2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

phenylhydrazine
100-63-0

phenylhydrazine

A

dipropyl-malonic acid mono-(N'-phenyl-hydrazide)

dipropyl-malonic acid mono-(N'-phenyl-hydrazide)

B

1-phenyl-3.5-dioxo-4.4-dipropyl-pyrazolidine

1-phenyl-3.5-dioxo-4.4-dipropyl-pyrazolidine

Conditions
ConditionsYield
With sodium ethanolate
2,2-dipropyl-malonic acid diethyl ester
6065-63-0

2,2-dipropyl-malonic acid diethyl ester

1-<2-Diaethylamino-aethoxy>-2,2-dipropyl-propanol-(3)
101082-35-3

1-<2-Diaethylamino-aethoxy>-2,2-dipropyl-propanol-(3)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / diethyl ether
2: (i) Na, benzene, (ii) /BRN= 605300/
View Scheme

6065-63-0Relevant articles and documents

Rethinking Basic Concepts-Hydrogenation of Alkenes Catalyzed by Bench-Stable Alkyl Mn(I) Complexes

Weber, Stefan,St?ger, Berthold,Veiros, Luis F.,Kirchner, Karl

, p. 9715 - 9720 (2019/10/14)

An efficient additive-free manganese-catalyzed hydrogenation of alkenes to alkanes with molecular hydrogen is described. This reaction is atom economic, implementing an inexpensive, earth-abundant nonprecious metal catalyst. The most efficient precatalyst is the bench-stable alkyl bisphosphine Mn(I) complex fac-[Mn(dippe)(CO)3(CH2CH2CH3)]. The catalytic process is initiated by migratory insertion of a CO ligand into the Mn-alkyl bond to yield an acyl intermediate which undergoes rapid hydrogenolysis to form the active 16e Mn(I) hydride catalyst [Mn(dippe)(CO)2(H)]. A range of mono- A nd disubstituted alkenes were efficiently converted into alkanes in good to excellent yields. The hydrogenation of 1-alkenes and 1,1-disubstituted alkenes proceeds at 25 °C, while 1,2-disubstituted alkenes require a reaction temperature of 60 °C. In all cases, a catalyst loading of 2 mol % and a hydrogen pressure of 50 bar were applied. A mechanism based on DFT calculations is presented, which is supported by preliminary experimental studies.

STABILIZATION OF ACTIVE METAL CATALYSTS AT METAL-ORGANIC FRAMEWORK NODES FOR HIGHLY EFFICIENT ORGANIC TRANSFORMATIONS

-

Paragraph 0322-0323; 0338, (2019/01/07)

Metal-organic framework (MOFs) compositions based on post?synthetic metalation of secondary building unit (SBU) terminal or bridging OH or OH2 groups with metal precursors or other post-synthetic manipulations are described. The MOFs provide a versatile family of recyclable and reusable single-site solid catalysts for catalyzing a variety of asymmetric organic transformations, including the regioselective boryiation and siiylation of benzyiic C—H bonds, the hydrogenation of aikenes, imines, carbonyls, nitroarenes, and heterocycles, hydroboration, hydrophosphination, and cyclization reactions. The solid catalysts can also be integrated into a flow reactor or a supercritical fluid reactor.

Visible-light-induced photocatalytic reductive transformations of organohalides

Kim, Hyejin,Lee, Chulbom

, p. 12303 - 12306 (2013/02/23)

A photo opportunity: A visible-light-excited iridium catalyst delivers electrons from an amine to an organohalide. The electron transfer then induces reductive scission of the carbon-halogen bond, generating the corresponding alkyl, alkenyl, and aryl radical that can undergo cyclization and hydrodehalogenation reactions. Copyright

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