22174-62-5

Upstream product

• 78-84-2 isobutyraldehyde 
• 536-74-3 phenylacetylene 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 139313-56-7 4-methyl-1-phenyl-pent-1-yn-3-ol 

Downstream Products

• 42049-53-6 (4-methylpent-1-yn-1-yl)benzene 
• 141821-03-6 (4-methylpenta-1,2-dien-1-yl)benzene 
• 33863-96-6 (4-methylpenta-1,2-diene-1,1-diyl)dibenzene 

Relevant academic research and scientific papers

Reductive Cleavage of Propargylic Ethers with Alkali Metal: Application to the Synthesis of Allenylboronates

Treatment of propargylic ethers with sodium dispersion in the presence of lithium iodide results in the generation of the corresponding carbanion species via cleavage of the propargylic C-O bond. The anionic species react with trimethoxyborane to yield th

Nucleophilic substitution of propargyl alcohols with aliphatic alcohols, aliphatic amines and heterocycles catalyzed by 4-nitrobenzenesulfonic acid: A scalable and metal-free process

It is aimed to provide a cost effective p-NBSA catalyzed nucleophilic substitution of propargyl alcohols with alcohols, amines and heterocycles, without employing corrosive and costly metal catalysts, toxic solvents and column chromatography for purification. A systematic study of CC, CN and CO bond formation and efficacy of the scalability have also been confirmed.

Generation of allenic/propargylic zirconium complexes and subsequent cross-coupling reactions: A facile synthesis of multisubstituted allenes

(Chemical Equation Presented) The β-alkoxide elimination reaction of propargylic ether with Negishi reagent leads to allenes and/or alkynes after hydrolysis. The product distribution is highly dependent on the substitution pattern of starting propargylic