22178-82-1

Basic information

• Product Name: 2H-1,4-Benzoxazine, 4-(chloroacetyl)-3,4-dihydro- (8CI,9CI)
• Synonyms: 1-(2H-Benzo[b][1,4]oxazin-4(3H)-yl)-2-chloroethanone;2H-1,4-Benzoxazine, 4-(chloroacetyl)-3,4-dihydro- (8CI,9CI);4-(chloroacetyl)-3,4-dihydro-2H-1,4-benzoxazine(SALTDATA: FREE);4-(chloroacetyl)-3,4-dihydro-2H-1,4-benzoxazine;4-(2-Chloroacetyl)-2H-1,4-benzoxazine, 97%
• CAS NO: 22178-82-1
• Molecular Formula: C₁₀H₁₀ClNO₂
• Molecular Weight: 211.6449
• Product Categories: ACETYLHALIDE
• Mol File: 22178-82-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 409.6°C at 760 mmHg
• Flash Point: 201.5°C
• Appearance: /
• Density: 1.314g/cm³
• Vapor Pressure: 6.43E-07mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 2H-1,4-Benzoxazine, 4-(chloroacetyl)-3,4-dihydro- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Benzoxazine, 4-(chloroacetyl)-3,4-dihydro- (8CI,9CI)(22178-82-1)
• EPA Substance Registry System: 2H-1,4-Benzoxazine, 4-(chloroacetyl)-3,4-dihydro- (8CI,9CI)(22178-82-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 22178-82-1(Hazardous Substances Data)

Usage

General Description

The chemical 2H-1,4-Benzoxazine, 4-(chloroacetyl)-3,4-dihydro- (8CI,9CI) is a heterocyclic compound with a benzene ring fused to a nitrogen-containing oxazine ring. It is also known as 4-(chloroacetyl)-3,4-dihydro-2H-1,4-benzoxazine. This chemical has a chlorine atom attached to an acetyl group, and it exists in a dihydro form. It is commonly used in organic synthesis and as a building block for various pharmaceuticals and agrochemicals. Additionally, it has potential applications in material science, such as in the production of polymers and resins. Overall, 2H-1,4-Benzoxazine, 4-(chloroacetyl)-3,4-dihydro- is a versatile chemical with diverse uses in different industries.

InChI:InChI=1/C10H10ClNO2/c11-7-10(13)12-5-6-14-9-4-2-1-3-8(9)12/h1-4H,5-7H2

Upstream product

• 5735-53-5 1,4-benzoxazine 
• 79-04-9 chloroacetyl chloride 
• 88-75-5 2-hydroxynitrobenzene 
• 95-55-6 2-amino-phenol 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 

Relevant articles and documents

Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core

With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer's disease, we synthesized and evaluated a novel series of indole-benzoxazinones (Family I) and benzoxazine-arylpiperazine derivatives (Family II) for potential human acetylcholinesterase (hAChE) inhibitory properties. The most active compounds 7a and 7d demonstrated effective inhibitory profiles with Ki values of 20.3 ± 0.9 μM and 20.2 ± 0.9 μM, respectively. Kinetic inhibition assays showed non-competitive inhibition of AChE by the tested compounds. According to our docking studies, the most active compounds from both series (Families I and II) showed a binding mode similar to donepezil and interact with the same residues.

Synthesis and antirheumatic activity of novel tetrahydroquinoline-8-carboxylic acid derivatives

A study of the modification of N-alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone destruction.