221887-36-1

Basic information

• Product Name: 2,2,2-tribromoethyl cyclohexanecarboxylate
• Synonyms: 2,2,2-tribromoethyl cyclohexanecarboxylate
• CAS NO: 221887-36-1
• Molecular Weight: 392.913
• Mol File: 221887-36-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2,2-tribromoethyl cyclohexanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-tribromoethyl cyclohexanecarboxylate(221887-36-1)
• EPA Substance Registry System: 2,2,2-tribromoethyl cyclohexanecarboxylate(221887-36-1)

Safety Data

• Hazardous Substances Data: 221887-36-1(Hazardous Substances Data)

Upstream product

• 75-80-9 2,2,2-tribromoethanol 
• 98-89-5 Cyclohexanecarboxylic acid 

Downstream Products

• 36364-14-4 2-methoxyethyl cyclohexanecarboxylate 
• 68366-66-5 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl cyclohexanecarboxylate 
• 5461-52-9 N,N-diethylcyclohexanecarboxamide 
• 128037-34-3 N-Butyl-cyclohexyl carboxamide 
• 22733-94-4 benzyl cyclohexanecarboxylate 
• 6553-81-7 butyl cyclohexanecarboxylate 
• 17566-51-7 N,N-dimethylcyclohexanecarboxamide 

Relevant articles and documents

Direct transacylation of 2,2,2-trihaloethyl esters with amines and alcohols using phosphorus(III) reagents for reductive fragmentation and in situ activation

Amides and esters have been synthesized from 2,2,2-trihaloethyl esters in one pot using phosphorus(III) reagents as reductants, with resultant carboxylate activation as an acyloxyphosphonium intermediate, and in situ trapping by amine or alcohol nucleophiles. Secondary and tertiary amides were synthesized, including a dipeptide, in good yields using hexamethylphosphorous triamide, (Me2N)3P, as reducing agent. Optimal yields of esters derived from primary and secondary alcohols were obtained using tributylphosphine and DMAP. Tribromoethyl esters provided yields superior to those obtained with trichloroethyl esters.