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22217-80-7

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22217-80-7 Usage

General Description

The chemical "5-(4-Methoxy-Phenyl)-3,4-Dihydro-2H-Pyrrole" is a unique compound with a complex structure. It contains a pyrrole ring, which is a five-membered aromatic ring with one nitrogen atom. The presence of a 4-Methoxy-Phenyl group further adds to its complexity, making it a potential building block for the synthesis of larger organic molecules. 5-(4-Methoxy-Phenyl)-3,4-Dihydro-2H-Pyrrole has the potential to be used in pharmaceuticals, agrochemicals, and materials science due to its interesting structural features and potential biological activity. Further research and analysis of this chemical could reveal its specific properties and potential applications in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 22217-80-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,1 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 22217-80:
(7*2)+(6*2)+(5*2)+(4*1)+(3*7)+(2*8)+(1*0)=77
77 % 10 = 7
So 22217-80-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO/c1-13-10-6-4-9(5-7-10)11-3-2-8-12-11/h4-7H,2-3,8H2,1H3

22217-80-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(4-methoxyphenyl)-3,4-dihydro-2H-pyrrole

1.2 Other means of identification

Product number -
Other names GL-1029

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22217-80-7 SDS

22217-80-7Relevant articles and documents

Identification of the first structurally validated covalent ligands of the small GTPase RAB27A

Armstrong, Alan,Brustur, Delia,Cota, Ernesto,Craven, Gregory B.,De Vita, Elena,Hassan, Sarah,Jamshidiha, Mostafa,Lanyon-Hogg, Thomas,Mann, David J.,Morgan, Rhodri M.,Norman, Jim C.,Pérez-Dorado, Inmaculada,Petracca, Rita,Sanz-Hernández, Máximo,Sutherell, Charlotte L.,Tate, Edward W.,Tersa, Montse

, p. 150 - 155 (2022/03/29)

Rab27A is a small GTPase, which mediates transport and docking of secretory vesicles at the plasma membrane via protein-protein interactions (PPIs) with effector proteins. Rab27A promotes the growth and invasion of multiple cancer types such as breast, lung and pancreatic, by enhancing secretion of chemokines, metalloproteases and exosomes. The significant role of Rab27A in multiple cancer types and the minor role in adults suggest that Rab27A may be a suitable target to disrupt cancer metastasis. Similar to many GTPases, the flat topology of the Rab27A-effector PPI interface and the high affinity for GTP make it a challenging target for inhibition by small molecules. Reported co-crystal structures show that several effectors of Rab27A interact with the Rab27A SF4 pocket ('WF-binding pocket') via a conserved tryptophan-phenylalanine (WF) dipeptide motif. To obtain structural insight into the ligandability of this pocket, a novel construct was designed fusing Rab27A to part of an effector protein (fRab27A), allowing crystallisation of Rab27A in high throughput. The paradigm of KRas covalent inhibitor development highlights the challenge presented by GTPase proteins as targets. However, taking advantage of two cysteine residues, C123 and C188, that flank the WF pocket and are unique to Rab27A and Rab27B among the >60 Rab family proteins, we used the quantitative Irreversible Tethering (qIT) assay to identify the first covalent ligands for native Rab27A. The binding modes of two hits were elucidated by co-crystallisation with fRab27A, exemplifying a platform for identifying suitable lead fragments for future development of competitive inhibitors of the Rab27A-effector interaction interface, corroborating the use of covalent libraries to tackle challenging targets. This journal is

Intramolecular Cyclization of Brominated Oxime Ether Promoted with Ytterbium(0) to the Synthesis of Cyclic Imines

Wang, Yiqiong,Huang, Fei,Zhang, Songlin

supporting information, p. 5178 - 5181 (2020/08/13)

The first utility of ytterbium(0) as a mediating-metal in the intramolecular cyclization of brominated oxime ether was reported in this paper. In contrast to the prior methods, the N–O bond was used as a receptor of nucleophilic reagent, rather than as a source of N-centered radicals. Cyclic imines were obtained in this one-pot reaction with a broad scope of substrates and feasible reaction conditions.

Intramolecular Csp3-H/C-C bond amination of alkyl azides for the selective synthesis of cyclic imines and tertiary amines

Jiao, Ning,Li, Xinyao,Luo, Xiao,Song, Song,Wang, Weijin,Wen, Xiaojin

, p. 4482 - 4487 (2020/05/18)

The intramolecular Csp3-H and/or C-C bond amination is very important in modern organic synthesis due to its efficiency in the construction of diversified N-heterocycles. Herein, we report a novel intramolecular cyclization of alkyl azides for the synthesis of cyclic imines and tertiary amines through selective Csp3-H and/or C-C bond cleavage. Two C-N single bonds or a CN double bond are efficiently constructed in these transformations. The carbocation mechanism differs from the reported metal nitrene intermediates and therefore enables metal-free and new transformation.

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