22226-37-5

Usage

Uses

Used in Pharmaceutical Industry:
α-formyl phenyl acetic acid tropine ester is used as a therapeutic agent for its potential in treating neurological and psychiatric disorders. Its ability to modulate neurotransmitter systems in the brain makes it a promising candidate for such applications.
Used in Neurological Disorders Treatment:
α-formyl phenyl acetic acid tropine ester is used as a treatment option for neurological disorders due to its potential to modulate neurotransmitter systems, which can help alleviate symptoms and improve the quality of life for patients.
Used in Psychiatric Disorders Treatment:
α-formyl phenyl acetic acid tropine ester is used as a treatment option for psychiatric disorders, leveraging its ability to modulate neurotransmitter systems in the brain to potentially alleviate symptoms and improve mental health.
Used as an Analgesic Agent:
α-formyl phenyl acetic acid tropine ester is used as an analgesic agent, given its potential to provide pain relief, which can be beneficial in managing various types of pain conditions.
Used as an Anti-inflammatory Agent:
α-formyl phenyl acetic acid tropine ester is used as an anti-inflammatory agent, which can help reduce inflammation and associated symptoms in various medical conditions.

Upstream product

• 59216-85-2 α-formyl phenyl acetic acid 
• 120-29-6 3-tropanol 
• 542-05-2 acetonedicarboxylic acid 
• 532-24-1 tropinone 
• 103-82-2 phenylacetic acid 
• 55-48-1 (1R,3r,5S)-3-tropoyloxytropanium sulfate 
• 5894-79-1 methyl 2-formyl-2-phenylacetate 

Downstream Products

• 51-55-8 Atropine 

Relevant academic research and scientific papers

Synthesis method of atropine sulfate

The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of atropine sulfate. The preparation method comprises the following steps: firstly preparing tropine ester, then preparing atropine, salifying to prepare atropine sulfate, and finally refining to obtain the product. In the preparation process of the tropine ester, the reaction temperature is strictly controlled to be 105-111 DEG C, and the crystallization temperature is controlled to be 0-5 DEG C, so that the yield of the tropine ester is improved. In the process of preparing atropine through reduction reaction, palladium-carbon is adopted as a catalyst, and the reaction temperature is strictly controlled to be 10-15 DEG C, so that the product quality is effectively improved. Sulfuric acid is diluted by preparing a sulfuric acid ethanol solution, and the dripping speed of the sulfuric acid ethanol solution is controlled, so that the stable quality of atropine sulfate is ensured.

Kinetics of oxidation of atropine by K2Cr2O7 in acidic aqueous solutions

Oxidation of atropine (ATN) by K2Cr2O7 has been studied kinetically in aqueous strongly acidic solutions. The kinetics of this reaction was investigated at different temperatures. A constant pH and constant ionic strength were maintained constant throughout all measurements. The concentration of atropine was around an order of magnitude greater than that of K2Cr2O7, that is under pseudo first order kinetics. Rate constants were obtained by monitoring change in absorbance of K2Cr2O7 with time at its predetermined maximum wavelength. Overall rate constant and the orders of the reaction in terms of concentrations of both atropine and K2Cr2O7 were determined. Reaction runs at different temperature allows activation energy of the process to be convoluted from temperature effect on the rate of the reaction. A resonable mechanism for the reaction was proposed in accordance with kinetics results.

CRYSTALLINE ATROPINE SULFATE

The present invention relates to crystalline polymorph form of Atropine sulfate and process for the preparation thereof.