α-formyl phenyl acetic acid tropine ester

Base Information

• Chemical Name: α-formyl phenyl acetic acid tropine ester
• CAS No.: 22226-37-5
• Molecular Formula: C₁₇H₂₁NO₃
• Molecular Weight: 287.359
• Mol file: 22226-37-5.mol

Synonyms:

Chemical Property of α-formyl phenyl acetic acid tropine ester

Chemical Property:

• Melting Point: 222-223 °C
• Boiling Point: 400.2±45.0 °C(Predicted)
• Density: 1.18±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-formyl phenyl acetic acid tropine ester

There total 6 articles about α-formyl phenyl acetic acid tropine ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 2-formyl-2-phenylacetate (5894-79-1) + 3-tropanol (120-29-6) → α-formyl phenyl acetic acid tropine ester (22226-37-5,1049970-26-4,60251-89-0)

Guidance literature:

In toluene; at 110 ℃; for 3h; Temperature; Large scale;

Reference yield:

α-formyl phenyl acetic acid (59216-85-2) + 3-tropanol (120-29-6) → α-formyl phenyl acetic acid tropine ester (22226-37-5,1049970-26-4,60251-89-0)

Guidance literature:

With sodium methylate; In toluene; at 109 - 115 ℃; for 5h;

Reference yield:

(1R,3r,5S)-3-tropoyloxytropanium sulfate (55-48-1,300-40-3,620-61-1,1867-24-9,2472-17-5,2623-69-0,14844-27-0,5908-99-6) → α-formyl phenyl acetic acid tropine ester (22226-37-5,1049970-26-4,60251-89-0)

Guidance literature:

With potassium dichromate; In water; at 25 ℃; for 0.416667h; Concentration; Temperature; Kinetics;

DOI:10.14233/ajchem.2018.21463

upstream raw materials:

α-formyl phenyl acetic acid

3-tropanol

acetonedicarboxylic acid

tropinone

Downstream raw materials:

Atropine

Refernces

• 1、 Abdel-Halim, Hamzeh M.,Saleh, Abdullah I.,Al-Ghreizat, Sanad K.. "Kinetics of oxidation of atropine by K2Cr2O7 in acidic aqueous solutions". . p. 2103 - 2106. Retrieved 2018/08/09.