713-41-7

Usage

Uses

Used in Pharmaceutical Applications:
2-amino-4-(trifluoromethyl)benzamide is used as an active pharmaceutical ingredient for its antifungal and antibacterial properties, contributing to the development of treatments for various infections caused by fungi and bacteria.
Used in Agricultural Applications:
In the agricultural industry, 2-amino-4-(trifluoromethyl)benzamide is used as a pesticide, leveraging its antifungal and antibacterial properties to protect crops from diseases and pests, thereby enhancing crop yield and quality.
Used in Organic Synthesis:
2-amino-4-(trifluoromethyl)benzamide is utilized as a building block in organic synthesis, enabling the creation of a variety of complex organic compounds for research and industrial applications.
Safety Precautions:
It is crucial to handle 2-amino-4-(trifluoromethyl)benzamide with care due to its potential to cause skin and eye irritation. It should be used in a well-ventilated area to minimize exposure risks.

InChI:InChI=1/C8H7F3N2O/c9-8(10,11)4-1-2-5(7(13)14)6(12)3-4/h1-3H,12H2,(H2,13,14)

Upstream product

• 778-94-9 2-nitro-4-trifluoromethyl-benzonitrile 
• 1483-54-1 2-amino-4-trifluoromethylbenzonitrile 
• 97928-01-3 7-trifluoromethyl-1,2-dihydro-3,1-benzoxazine-2,4-dione 
• 402-13-1 2-amino-4-trifluoromethylbenzoic acid 
• 22227-55-0 2-nitro-4-trifluoromethyl benzamide 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 

Downstream Products

• 1241915-06-9 2-((4-fluorophenyl)(hydroxy)methyl)-7-(trifluoromethyl)quinazolin-4-ol 
• 16499-58-4 7-(trifluoromethyl)quinazolin-4(3H)-one 
• 1278580-30-5 4-chloro-2-(4-chlorophenyl)-7-trifluoromethyl-quinazoline 
• 1278573-27-5 [2-(4-chlorophenyl)-7-trifluoromethyl-quinazolin-4-yl]ethylamine 
• 1278580-27-0 2-(4-chlorophenyl)-7-trifluoromethyl-3H-quinazolin-4-one 
• 402-13-1 2-amino-4-trifluoromethylbenzoic acid 
• 1241915-05-8 2-(2-(4-fluorophenyl)-2-hydroxyacetamido)-4-(trifluoromethyl)benzamide 

Relevant academic research and scientific papers

MEMBRANE-ACTIVE ANTI-BACTERIAL COMPOUNDS AND USES THEREOF

In an embodiment, the present disclosure pertains to methods of inhibiting bacterial growth. Generally, the methods include exposing bacteria to an anti-bacterial compound as disclosed herein. In some embodiments, the exposing occurs in vivo in a subject in order to treat or prevent a bacterial infection. In additional embodiments, the present disclosure pertains to anti- bacterial compounds that are suitable for inhibiting bacterial growth.

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1–3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1–3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L?1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L?1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Trash to treasure: Eco-friendly and practical synthesis of amides by nitriles hydrolysis in WepPA

The hydration of nitriles to amides in a water extract of pomelo peel ash (WEPPA) was realized with moderate to excellent yields without using external transition metals, bases or organic solvents. This reaction features a broad substrate scope, wide functional group tolerance, prominent chemoselectivity, and good reusability. Notably, a magnification experiment in this bio-based solvent at 100 mmol further demonstrated its practicability.

ADENOSINE A3 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF

Provided herein is a method of preventing, treating, or ameliorating one or more symptoms of an adenosine A3-mediated condition, disorder, or disease, with a compound of Formula I. Also provided herein is a method of preventing, treating, or ameliorating one or more symptoms of glaucoma or ocular hypertension. Further provided herein is a method of modulating the activity of an adenosine A3 receptor.

JAK KINASE MODULATING QUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF

Provided herein are quinazoline compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions. (I).

Palladium-catalyzed silane/siloxane reductions in the one-pot conversion of nitro compounds into their amines, hydroxylamines, amides, sulfonamides, and carbamates

A combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS) facilitates the room-temperature reduction of aromatic nitro compounds to anilines. These reactions tend to be quick (30 min), high-yielding, and tolerate a range of other functional groups. Replacement of PMHS/KF with triethylsilane allows for the reduction of aliphatic nitro compounds to their corresponding hydroxylamines. Depending on the substrate, both conditions can allow for the in situ conversion of the product amines into amides, sulfonamides, and carbamates. Georg Thieme Verlag Stuttgart.

CAPSAICIN RECEPTOR AGONISTS

Capsaicin receptor agonists are provided. Such compounds are ligands that may be used to modulate VRl activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to capsaicin receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Concerning the baker's yeast (Saccharomyces cerevisiae) mediated reduction of nitroarenes and other N-O containing functional groups

Nitro- and nitrosoarenes can be reduced using baker's yeast (Saccharomyces cerevisiae) under two distinct sets of conditions, one of which is in fact a well established non-enzymic process. In order to clarify reports in the literature a comparison of the two methods has been made.