22235-25-2

Basic information

• Product Name: 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER
• Synonyms: 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER;METHYL 3-AMINO-5-(TRIFLUOROMETHYL)BENZOATE;BUTTPARK 88\11-03
• CAS NO: 22235-25-2
• Molecular Formula: C₉H₈F₃NO₂
• Molecular Weight: 219.16
• Product Categories: pharmacetical
• Mol File: 22235-25-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 292.8°C at 760 mmHg
• Flash Point: 130.9°C
• Appearance: /
• Density: 1.343g/cm³
• Vapor Pressure: 0.00179mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER(22235-25-2)
• EPA Substance Registry System: 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER(22235-25-2)

Safety Data

• Hazardous Substances Data: 22235-25-2(Hazardous Substances Data)

Usage

General Description

3-Amino-5-trifluoromethyl-benzoic acid methyl ester is a specialized chemical compound featured prominently in scientific and industrial contexts. Structurally, the compound is characterized by its benzene ring, which is substituted by a trifluoromethyl group, an amino group and a carboxylic acid methyl ester. Its molecular formula is C9H8F3NO2, indicating the presence of nine carbon atoms, eight hydrogen atoms, three fluorine atoms, one nitrogen atom, and two oxygen atoms. Its unique structure grants it particular reactive properties, useful in a range of applications, for example, as an intermediate in organic syntheses. Like many similar compounds, professional handling is recommended due to uncertain health and safety profiles.

InChI:InChI=1/C9H8F3NO2/c1-15-8(14)5-2-6(9(10,11)12)4-7(13)3-5/h2-4H,13H2,1H3

Upstream product

• 67-56-1 methanol 
• 328-80-3 3-nitro-5-trifluoromethyl-benzoic acid 
• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 328-68-7 3-amino-5-(trifluoromethyl)benzoic acid 
• 22227-63-0 methyl 3-nitro-5-(trifluoromethyl)-benzoate 

Downstream Products

• 334792-87-9 Methyl 3-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)benzoate 
• 632624-47-6 3-{2-[5-chloro-2-(2,3-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-trifluoromethylbenzoic acid 

Relevant articles and documents

UREA DERIVATIVE AND USE THEREFOR

The purpose of the present invention is to provide a compound with inhibitory activity on Discoidin Domain Receptor 1. The present invention provides a urea derivative represented by the formula below or a pharmaceutically acceptable salt thereof.

Enantioselective Synthesis of Quaternary Δ4- and Δ5-Dehydroprolines Based on a Two-Step Formal [3+2] Cycloaddition of α-Aryl and α-Alkyl Isocyano(thio)acetates with Vinyl Ketones

A divergent synthesis of optically active quaternary Δ4- and Δ5-dehydro prolines is developed based on the first catalytic enantioselective conjugate addition of α-substituted isocyano(thio)acetates to vinyl ketones that is general for both α-aryl and α-alkyl isocyano(thio)acetates. The new tetrasubstituted C?N stereocenter is formed without the need of any metal salt due to a bifunctional tertiary amine/squaramide catalyst, featuring a bulky polyaryl sidearm and an unusually short squaramide diamide H???H interatomic distance in the solid state.

PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS

JAK1 inhibitors of structural formula (I), wherein Ar1, Ar2, Q, W, X, Y, and Z are defined in the specification, pharmaceutically acceptable salts thereof, compositions thereof, and use of the compounds and compositions for treating diseases. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases.