22244-94-6Relevant academic research and scientific papers
NIS-promoted multicomponent reaction of 2-aminopyridines with aldehydes and nitromethane for the synthesis of 3-nitroimidazo[1.2-a]pyridines
Sun, Jinwei,Yang, Xinrui,Liu, Yun,Wang, Yi,Pan, Yi
, p. 1449 - 1455 (2020/02/05)
An efficient synthesis of 3-nitroimidazo[1,2-a]pyridines has been developed via N-iodosuccinimide (NIS)-mediated multicomponents reaction of 2-aminopyridines, aldehydes, and nitromethane under metal-free conditions. This protocol has many advantages such as broad substituent scope, mild and eco-friendly conditions, high step economy, and good yields.
Synthesis of 3-Nitro-2-arylimidazo[1,2- a ]pyridines Using Sodium Dichloro?-iodide
Jagadhane, Prashant B.,Telvekar, Vikas N.
, p. 2636 - 2638 (2015/01/09)
Moderate to good yields of various 3-nitro-2-arylimidazo[1,2-a]pyridines have been easily achieved in the reaction of 2-aminopyridines and nitrostyrenes in the presence of sodium dichloriodide. The procedure is simple and various functional groups are tol
Synthesis of 3-nitro-2-arylimidazo[1,2- a ]pyridines using sodium dichloro-iodide
Jagadhane, Prashant B.,Telvekar, Vikas N.
, (2015/08/06)
Moderate to good yields of various 3-nitro-2-arylimidazo[1,2-a]pyridines have been easily achieved in the reaction of 2-aminopyridines and nitrostyrenes in the presence of sodium dichloriodide. The procedure is simple and various functional groups are tol
Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a] pyridine: Expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines
Bazin, Marc-Antoine,Marhadour, Sophie,Tonnerre, Alain,Marchand, Pascal
, p. 5378 - 5382 (2013/09/12)
Alternative strategies for functionalizing 2-chloro-3-nitroimidazo[1,2-a] pyridine have been developed. Suzuki-Miyaura cross-coupling reaction provided easily the corresponding 2-arylated compounds, and herefrom the nitro group was reduced into amine which afforded amides, anilines, and ureas in the 3-position. The amination of the key compound using a metal-catalyzed reaction was reported. This study highlighted the importance of the nitro group to facilitate the chlorine displacement. Other nucleophilic aromatic substitutions open a route to various products derived from imidazo[1,2-a]pyridine.
Influence of the 2-aryl group on the ipso electrophilic substitution process of 2-arylimidazo[1,2-a]pyridines
Salgado-Zamora, Hector,Velazquez, Manuel,Mejia, Daniel,Campos-Aldrete,Jimenez, Rogelio,Cervantes, Humberto
, p. 27 - 32 (2008/09/19)
A systematic study of electrophilic substitution reactions of 3-nitroso-2-arylimidazo[1,2-a]pyridine confirmed that the nitroso group may be ipso-substituted by bromine (NBS in DMF) and that bromine in turn may be substituted by the nitroso group. Electro
