4926-52-7

Usage

Uses

Used in Pharmaceutical Industry:
Imidazo[1,2-a]pyridine,2-chloro-3-nitrois used as a key intermediate in the synthesis of various drugs and pharmaceuticals for its potential to exhibit a wide range of biological activities. Its versatile reactivity and structural features make it a valuable component in the development of new therapeutic agents.
Used in Agrochemical Industry:
Imidazo[1,2-a]pyridine,2-chloro-3-nitrois utilized as a building block in the production of agrochemicals, particularly those with antibacterial, antifungal, and antiviral properties. Its application in this industry contributes to the development of effective solutions for crop protection and disease management.
Used in Medicinal Chemistry Research:
Imidazo[1,2-a]pyridine,2-chloro-3-nitroserves as a significant compound in medicinal chemistry research, where it is studied for its potential applications in the discovery and development of novel therapeutic agents. Its diverse biological activities and structural features make it a promising candidate for further exploration and innovation in the field of drug design and synthesis.
Used in Organic Chemistry:
Imidazo[1,2-a]pyridine,2-chloro-3-nitrois an important compound in organic chemistry, where it is employed in various chemical reactions and synthesis processes. Its unique structural features and reactivity contribute to the advancement of organic chemistry, enabling the creation of new chemical entities and compounds with potential applications in various industries.

InChI:InChI=1/C7H4ClN3O2/c8-6-7(11(12)13)10-4-2-1-3-5(10)9-6/h1-4H

Upstream product

• 504-29-0 2-aminopyridine 
• 3999-05-1 2-chloroimidazo[1,2-a]pyridine 
• 126202-06-0 2-(2-imino-1,2-dihydropyridin-1-yl)acetic acid 

Downstream Products

• 3999-29-9 2-phenylimidazo[1,2-a]pyridin-3-amine 
• 171628-63-0 1-Phenyl-3-(2-phenyl-imidazo[1,2-a]pyridin-3-yl)-urea 
• 1110272-22-4 N,2-diphenylimidazo[1,2-a]pyridin-3-amine 
• 1072106-67-2 C₁₉H₁₄N₄O₂ 
• 1452807-22-5 N-(4-chlorophenyl)-2-phenylimidazo[1,2-a]pyridin-3-amine 
• 1452807-23-6 2-phenyl-N-(pyridin-3-yl)imidazo[1,2-a]pyridin-3-amine 
• 82193-32-6 3-amino-2-cyanoimidazo[1,2-a]pyridine 
• 956077-87-5 2-(4-methoxyphenyl)-3-nitroimidazo[1,2-a]pyridine 
• 1452807-18-9 2-(4-fluorophenyl)-3-nitroimidazo[1,2-a]pyridine 
• 22244-94-6 3-nitro-2-(4'-nitrophenyl)imidazo[1,2-a]pyridine 
• 1452807-24-7 C₁₃H₁₀N₄O₂ 

Relevant academic research and scientific papers

Synthesis and antibacterial activity in?vitro of 2-benzylthioimidazo[1,2-a]pyridine derivatives against pathogenic bacterial

To explore the antibacterial activity, a set of new 2-thiobenzyl-3-nitro-imidazo[1,2-a]pyridine derivatives were synthesized (9a–h) and characterized by NMR 1H, 13C and high-resolution mass (HRMS). These compounds were obtained by interaction between the 3-nitro-imidazo[1,2-a]pyridine isothiouronium salt (7) with benzyl chloride or bromide (8) in the presence of sodium hydroxide (NaOH). Eight (9a–h) of them were evaluated in?vitro on the positive gram bacterium (S. aureus ATCC 29213) and two others negative gram bacteria (P. aeruginosa ATCC 27853 and P. aeruginosa 933 C/21) by methods diffusion in solid medium and liquid macrodilution. Five among the eight compounds (9a, 9d, 9h, 9f and 9g) showed significant antibacterial activity on P. aeruginosa ATCC 27853 and P. aeruginosa 933 C/21with MIC between 7.81 and 250 μg/mL. All compounds were inactive on S. aureus. The compounds 9a and 9g were more potent on the two strains of P. aeruginosa ATCC 27853.

Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors

Despite the therapeutic relevance of δ-containing γ-aminobutyric acid type A receptors (GABAARs) and the need for δ-selective compounds, the structural determinants for the mode and molecular site of action of δ-selective positive allosteric modulator imi

Pyridino-imidazopyrrole compound and application thereof

The invention provides a pyridino-imidazopyrrole compound, and belongs to the technical field of organic electroluminescent functional materials. The structural general formula is shown as a formula (I) or a formula (II), wherein in the formula (I) or the formula (II), R1, R2 and R3 are independently selected from hydrogen, C6-C16 aryl, a nitrogen atom-containing electron donating group or a nitrogen atom-containing electron withdrawing group respectively, and at least one of R1, R2 and R3 is a nitrogen atom-containing electron donating group. The compound provided by the invention has relatively balanced carrier transport performance, relatively high triplet state energy level and relatively high glass-transition temperature, is not easy to crystallize, has good thermal stability and film-forming property, can be used as a main body material, a sensitizing material and a doping material to be applied to a light-emitting layer of an organic light-emitting device, and the luminous efficiency and the service life of the device are effectively improved. The structural general formula is shown as the formula (I) or the formula (II).

Pyrrolo-imidazo[1,2- A[pyridine Scaffolds through a Sequential Coupling of N-Tosylhydrazones with Imidazopyridines and Reductive Cadogan Annulation, Synthetic Scope, and Application

A new strategy for the construction of 3-phenyl-1H-pyrrolo-imidazo[1,2-a]pyridine backbone is described. The reaction starts from the coupling between N-tosylhydrazones and 2-chloro-3-nitroimidazo[1,2-a]pyridines leading to the formation of 3-nitro-2-(ary

HETERO-CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

The present specification relates to a novel heterocyclic compound and an organic light-emitting device using the same. According to one embodiment of the present specification, provided is a compound in chemical formula 1. The compound of the present specification can be used as an organic matter layer material of an organic light-emitting device.COPYRIGHT KIPO 2016

Facile synthesis, structural evaluation, antimicrobial activity and synergistic effects of novel imidazo[1,2-a]pyridine based organoselenium compounds

A simple and efficient method has been described to synthesize the hitherto unknown imidazo[1,2-a]pyridine selenides (5a-l) by reaction of 2-chloroimidazo [1,2-a]pyridines with aryl/heteroaryl selenols, generated in situ by reduction of various diselenide

Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a] pyridine: Expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

Alternative strategies for functionalizing 2-chloro-3-nitroimidazo[1,2-a] pyridine have been developed. Suzuki-Miyaura cross-coupling reaction provided easily the corresponding 2-arylated compounds, and herefrom the nitro group was reduced into amine which afforded amides, anilines, and ureas in the 3-position. The amination of the key compound using a metal-catalyzed reaction was reported. This study highlighted the importance of the nitro group to facilitate the chlorine displacement. Other nucleophilic aromatic substitutions open a route to various products derived from imidazo[1,2-a]pyridine.