222620-67-9Relevant academic research and scientific papers
In vitro photo-release of a TRPV1 agonist
Carr, James L.,Wease, Kerrie N.,Van Ryssen, Michael P.,Paterson, Suzanne,Agate, Ben,Gallagher, Katherine A.,Brown, C. Tom A.,Scott, Roderick H.,Conway, Stuart J.
, p. 208 - 212 (2006)
Intracellular photolysis of a novel 'caged' capsaicin analogue results in in vitro activation of the capsaicin receptor TRPV1.
Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists
Van Ryssen, Michael P.,Avlonitis, Nicolaos,Giniatullin, Rashid,McDougall, Craig,Carr, James L.,Stanton-Humphreys, Megan N.,Borgstroem, Emma L. A.,Brown, C. Tom A.,Fayuk, Dmitriy,Surin, Alexander,Niittykoski, Minna,Khiroug, Leonard,Conway, Stuart J.
experimental part, p. 4695 - 4707 (2009/12/08)
The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.
