222622-85-7Relevant articles and documents
Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists
Van Ryssen, Michael P.,Avlonitis, Nicolaos,Giniatullin, Rashid,McDougall, Craig,Carr, James L.,Stanton-Humphreys, Megan N.,Borgstroem, Emma L. A.,Brown, C. Tom A.,Fayuk, Dmitriy,Surin, Alexander,Niittykoski, Minna,Khiroug, Leonard,Conway, Stuart J.
experimental part, p. 4695 - 4707 (2009/12/08)
The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.
