871570-36-4Relevant academic research and scientific papers
Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation
Donslund, Aske S.,Pedersen, Simon S.,Gaardbo, Cecilie,Neumann, Karoline T.,Kingston, Lee,Elmore, Charles S.,Skrydstrup, Troels
, p. 8099 - 8103 (2020/03/16)
An extensive range of functionalized aliphatic ketones with good functional-group tolerance has been prepared by a NiI-promoted coupling of either primary or secondary alkyl iodides with NN2 pincer NiII-acyl complexes. The latter were easily accessed from the corresponding NiII-alkyl complexes with stoichiometric CO. This Ni-mediated carbonylative coupling is adaptable to late-stage carbon isotope labeling, as illustrated by the preparation of isotopically labelled pharmaceuticals. Preliminary investigations suggest the intermediacy of carbon-centered radicals.
Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists
Van Ryssen, Michael P.,Avlonitis, Nicolaos,Giniatullin, Rashid,McDougall, Craig,Carr, James L.,Stanton-Humphreys, Megan N.,Borgstroem, Emma L. A.,Brown, C. Tom A.,Fayuk, Dmitriy,Surin, Alexander,Niittykoski, Minna,Khiroug, Leonard,Conway, Stuart J.
experimental part, p. 4695 - 4707 (2009/12/08)
The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.
In vitro photo-release of a TRPV1 agonist
Carr, James L.,Wease, Kerrie N.,Van Ryssen, Michael P.,Paterson, Suzanne,Agate, Ben,Gallagher, Katherine A.,Brown, C. Tom A.,Scott, Roderick H.,Conway, Stuart J.
, p. 208 - 212 (2007/10/03)
Intracellular photolysis of a novel 'caged' capsaicin analogue results in in vitro activation of the capsaicin receptor TRPV1.
