2227-61-4

Basic information

• Product Name: 4-Phenyl-2-(p-tolyl)thiazole, 97%
• Synonyms: 4-Phenyl-2-(p-tolyl)thiazole, 97%;2-(4-Methylphenyl)-4-phenylthiazole, 97%
• CAS NO: 2227-61-4
• Molecular Formula: C₁₆H₁₃NS
• Molecular Weight: 251.34612
• Mol File: 2227-61-4.mol

Chemical Properties

• Melting Point: 56-59℃
• Boiling Point: 419.6±48.0 °C(Predicted)
• Appearance: /
• Density: 1.147±0.06 g/cm3(Predicted)
• PKA: 2.02±0.10(Predicted)
• CAS DataBase Reference: 4-Phenyl-2-(p-tolyl)thiazole, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenyl-2-(p-tolyl)thiazole, 97%(2227-61-4)
• EPA Substance Registry System: 4-Phenyl-2-(p-tolyl)thiazole, 97%(2227-61-4)

Safety Data

• Hazardous Substances Data: 2227-61-4(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 104-84-7 para-methylbenzylamine 
• 5720-05-8 4-methylphenylboronic acid 
• 5399-30-4 2-oxo-2-phenylethylthiocyanate 
• 4098-17-3 1-(1-azido-2-iodoethyl)benzene 
• 61750-20-7 morpholino(p-tolyl)methanethione 
• 100-41-4 ethylbenzene 
• 27088-83-1 2-(4-Methylphenyl)thiazole 
• 98-80-6 phenylboronic acid 
• 624-31-7 4-tolyl iodide 
• 2362-62-1 4-methylthiobenzamide 
• 152716-92-2 1H-1-(1'-phenylethynyl)-5-methyl-1,2,3-benziodoxathiole 3,3-dioxide 
• 874-60-2 4-methyl-benzoyl chloride 
• 66380-08-3 3-methyl-4-phenyl-5-thioxo-2-p-tolyl-4,5-dihydro-thiazolium betaine 

Downstream Products

• 25179-47-9 4-(2-p-tolyl-thiazol-4-yl)-aniline 
• 120332-22-1 [4-(4-Phenyl-thiazol-2-yl)-benzyl]-phosphonic acid diethyl ester 
• 1217863-59-6 2-(4-Bromomethyl-phenyl)-4-phenyl-thiazole 
• 25179-46-8 4-(4-nitrophenyl)-2-(p-tolyl)thiazole 

Relevant articles and documents

Br?nsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source

A Br?nsted acid-promoted sulfuration/annulation reaction for the one-pot synthesis of bis-substituted thiazoles from benzylamines, acetophenones, and sulfur powder has been developed. One C-N bond and multi C-S bonds were selectively formed in one pot. The choice of the Br?nsted acid was the key to the high efficiency of this transformation under metal-free conditions.

Cascade reactions to 2,4-disubstituted thiazoles via ligand-free palladium(II)-catalyzed C(sp)–C(sp2) coupling

A simple construction for various 2,4-disubstituted thiazoles via palladium(II)-catalyzed C(sp)–C(sp2) and C-N cascade coupling reactions was developed. Various substrates can be tolerated with good yields. And its ligand-free condition demonst

2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas

Treatment of alkylarenes with N-bromosuccinimide in a mixture of ethyl acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of diethyl carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino- 4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, respectively, in one pot. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions.

Preparation method of 2-aryl-4-alkyl thiazole compound

The invention discloses a preparation method of a 2-aryl-4-alkyl thiazole compound. In a solvent, a 2-thiocyanate ethanon compound reacts with a substituent phenylboronic acid compound under catalysisof palladium acetate, and the reactant is post-processe

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Several straightforward and practical processes have been established for the construction of 2-aminothiazoles, 1,3-thiazoles and 1,3-selenazoles from aryliodoazides. These strategies successfully proceed with a wide spectrum of substituted thioamides and its derivatives producing the resulting five-membered heterocycles obtained in satisfactory yields. The unique features of these protocols are operational simplicity and highly functional group tolerance, which make them convenient and practical routes for the preparation of various libraries of 2-aminothiazoles, 1,3-thiazoles, and 1,3-selenazoles.

Programmed synthesis of arylthiazoles through sequential C-H couplings

A programmed synthesis of privileged arylthiazoles via sequential C-H couplings catalyzed by palladium or nickel catalysts has been accomplished. This versatile protocol can supply all possible arylthiazole substitution patterns (2-aryl, 4-aryl, 5-aryl, 2

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Thiazoles were obtained in high yields by the reaction of 1H-1 -(1′-alkynyl)-5-methyl-1,2,3-benziodoxathiole 3,3-dioxides, which were easily prepared from the reaction of 1H-1-hydroxy-5-methyl-1,2,3- benziodoxathiole 3,3-dioxide and 1-alkynes, with thioam

SYNTHESIS AND REACTIONS OF 2-(HYDROXYIMINO)-2-PHENYLETHYL ARENEDITHIOCARBOXYLATES. A NEW SYNTHESIS OF 2,4-DIARYLTHIAZOLES

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NOVEL CYCLIZATION OF 2-(HYDROXYIMINO)-2-PHENYLETHYL DITHIOCARBOXYLATES

2-(Hydroxyimino)-2-phenylethyl arenedithiocarboxylates were cyclized to isothiazoles by the treatment with tosyl isocyanate.

An Improved of α-(Thioacylthio)methylphenyl-Ketones using Caesium Dithioates and a Convenient Synthesis of 2,4-Disubstituted 1,3-Thiazoles via the Ketones

α-(Thioacylthio)methylphenylketones were found to be obtained in almost quantitative yields from caesium dithioates and α-phenacyl bromide.Refluxing of these ketones with ammonium acetate in gracial acetic acid affords the corresponding 2,4-disubstituted