61750-20-7

Upstream product

• 110-91-8 morpholine 
• 60410-77-7 bis(4-methylbenzenethiocarbonyl) sulphide 
• 53437-15-3 morpholine-4-sulfenyl chloride 
• 89980-67-6 p-methylbenzylmagnesium bromide 
• 104-85-8 para-methylbenzonitrile 
• 106-42-3 para-xylene 
• 7559-36-6 4-methyl-β-nitrostyrene 
• 1696-20-4 4-acetylmorpholine 
• 104-87-0 4-methyl-benzaldehyde 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 2789-88-0 1,2-bis(4-methylphenyl)acetylene 
• 766-97-2 4-n-methylphenylacetylene 
• 622-47-9 4-tolylacetic acid 
• 2362-77-8 (4-methylbenzylidene)phenylamine 

Downstream Products

• 134-84-9 4-Methylbenzophenone 
• 1671-77-8 n-butyl p-tolyl ketone 
• 111097-40-6 4-(1-p-Tolyl-pentyl)-morpholine 
• 122-00-9 para-methylacetophenone 
• 99-94-5 p-Toluic acid 
• 85810-86-2 C₁₃H₁₈NOS⁽¹⁺⁾*I^(1-) 
• 1310487-43-4 (Z)-S-2-(4-methylbenzylidene)-3-oxobutyl 4-methylbenzothioate 
• 2227-61-4 4-phenyl-2-(4′-methylphenyl)thiazole 
• 1264748-32-4 C₁₈H₂₂OS 
• 1314692-71-1 C₁₀H₁₀O₃S 
• 1314692-68-6 C₂₂H₁₈O₂S 

Relevant academic research and scientific papers

Metal-free three-component synthesis of thioamides from β-nitrostyrenes, amines and elemental sulfur

A metal-free C[dbnd]C bond cleavage reaction of β-nitrostyrenes in the presence of elemental sulfur and secondary amines/amides is described. Elemental sulfur serves as both a raw material and an oxidant for C[dbnd]C bond cleavage, and secondary amines or amides are both feasible nitrogen sources. Besides mild reaction condition and simple work-up procedure, the method provided thioamides with good to excellent yields.

Mixed bases mediated synthesis of thioamides in water

A mixed bases mediated protocol is developed to synthesize thioamides from N-aryl or N-alkylamide, aldehyde and elemental sulfur in water. This reaction requires no addition of external oxidant and avoids large excess of amides. Various functional groups

Willgerodt-Kindler reaction at room temperature: Synthesis of thioamides from aromatic aldehydes and cyclic secondary amines

A simple method for the synthesis of thioamide derivatives in DMSO at room temperature and at 120 °C has been developed. Total 27 compounds were prepared under both conditions via a one-pot, three component reaction between substituted aromatic aldehydes,

Transition-Metal-Free Cleavage of C-C Triple Bonds in Aromatic Alkynes with S8 and Amides Leading to Aryl Thioamides

A novel transition-metal-free cleavage reaction of C-C triple bonds in aromatic alkynes with S8 and amides furnishes aryl thioamides in moderate to excellent yields. The remarkable features of this thioamidation include the metal-free cleavage of C-C triple bond, mild reaction conditions, as well as wide substrate scope that is particularly compatible with some internal aromatic alkynes and acetamides.

Sulfated polyborate catalyzed Kindler reaction: a rapid, efficient, and green protocol

A rapid, green, and efficient one-pot, three-component Kindler reaction was developed using a sulfated polyborate catalyst. The method described the reaction of aldehydes, amines/ammonium acetate, and sulfur for the synthesis of thioamides using sulfated polyborate under a solvent free condition at 100?°C. The key features of the present protocol are high yields, short reaction time, easy workup, and recyclability of a catalyst which gives economical as well as ecological rewards. The present method also has an ability to tolerate a variety of functional groups. Graphical abstract: [Figure not available: see fulltext.].

Direct conversion of methylarenes into dithiocarbamates, thioamides and benzyl esters

A new strategy for the synthesis of a variety of dithiocarbamates and thioamides has been developed employing inexpensive and readily available methylarenes under metal-free and solvent-free conditions. The approach offers a one-pot procedure and has also been extended to the synthesis of a diverse range of benzyl esters.

Zinc chloride catalyzed ring opening of N-arylsulfonyl aziridines by thioamides: A new approach to the synthesis of amidines

The first zinc chloride catalyzed ring opening of N-arylsulfonyl aziridines by thioamides is described. Various thioamides were reacted with N-arylsulfonyl aziridines in the presence of a catalytic amount of dry zinc chloride to provide the corresponding

Decarboxylative thioamidation of arylacetic and cinnamic acids: A new approach to thioamides

A new decarboxylative strategy has been developed for the synthesis of thioamides via a three-component reaction involving arylacetic or cinnamic acids, amines and elemental sulfur powder, without the need of a transition metal and an external oxidant.

Efficient one-step synthesis of benzazoles in aqueous media

Benzazoles (benzoxazoles, benzothiazoles, and benzimidazoles) were efficiently prepared by the aquatic reaction of the corresponding thioamidinium salts and 2-aminophenol, 2-aminothiophenol, and 1,2-diaminobenzene, respectively. The thioamidinium salt was successfully applied as an alternative to a carboxylic acid derivative to react smoothly with an amino precursor and in the presence of catalytic amounts of hexadecyltrimethylammonium bromide salt to produce benzazoles in good to excellent yields. Wiley-VCH Verlag GmbH & Co. KGaA 2009.