22282-65-1

Usage

Uses

Used in Pharmaceutical Industry:
4-Iodo-2-methylpyridine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Iodo-2-methylpyridine serves as a building block in the creation of agrochemicals, aiding in the production of compounds that can enhance crop protection and yield.
Used in Organic Chemistry:
4-Iodo-2-methylpyridine is utilized as a reagent in a wide range of chemical reactions, making it an indispensable tool for organic chemists in the synthesis of various organic compounds.
Used in Production of Chiral Ligands and Biologically Active Molecules:
4-Iodo-2-methylpyridine is employed as a precursor in the production of chiral ligands and biologically active molecules, which are essential in asymmetric catalysis and the development of pharmaceuticals with specific biological activities.
It is crucial to handle 4-Iodo-2-methylpyridine with caution due to its irritant and toxic properties, ensuring safety in its applications across industries.

InChI:InChI=1/C6H6IN/c1-5-4-6(7)2-3-8-5/h2-4H,1H3

Upstream product

• 79534-90-0 2-methyl-4-(trimethylstannyl)pyridine 
• 565237-08-3 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-chloropyridine 
• 75-36-5 acetyl chloride 
• 22282-99-1 4-bromo-2-methylpyridine 
• 63071-10-3 (4-chloropyridin-2-yl)methanol 
• 1121-76-2 4-chloropyridine N-oxide 
• 3678-63-5 4-chIoro-2-methylpyridine 
• 18437-58-6 3-methyl-4-pyridinamine 

Downstream Products

• 712-61-8 2,2'-dimethyl-4,4'-bipyridine 
• 33474-76-9 2-methyl-4(E)-styrylpyridine 
• 84586-39-0 (E)-2-methyl-4-pyridineacrylonitrile 
• 84586-38-9 (E)-ethyl 3-(2-methylpyridin-4-yl)acrylate 

Relevant academic research and scientific papers

Rapid and efficient copper-catalyzed finkelstein reaction of (hetero)aromatics under continuous-flow conditions

A general, rapid, and efficient method for the copper-catalyzed Finkelstein reaction of (hetero)aromatics has been developed using continuous flow to generate a variety of aryl iodides. The described method can tolerate a broad spectrum of functional groups, including N-H and O-H groups. Additionally, in lieu of isolation, the aryl iodide solutions were used in two distinct multistep continuous-flow processes (amidation and Mg-I exchange/nucleophilic addition) to demonstrate the flexibility of this method.

COMPOUNDS USEFUL AS A3 ADENOSINE RECEPTOR AGONISTS

Compounds useful as A3 Adenosine Receptor Agonists. Adenosine analogue-type A3 receptor agonists having an N6 substituent of the formula CR20R21CYCLE where CYCLE is a specified heterocycle, e.g. a substituted pyridyl group or a substituted oxazolyl-containing bicyclic ring. 10

IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES

4-[1-Aryl-imidazol-4-ylethynyl]-2-alkyl-pyridine and 1-heteroaryl-imidazol-4-ylethynyl]-2-alkyl-pyridine derivatives and pharmaceutically acceptable salts thereof for the treatment or prevention of disorders mediated full or in part by metabotropic glutamate receptor 5, e.g. acute, traumatic and chronic degenerative processes of the nervous system, such as Alzheimer's disease, senile dementia, Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis and multiple sclerosis, psychiatric diseases such as schizophrenia and anxiety, depression, pain and drug dependency.

Substituted 4-phenyl-pyridine compounds with activity as antagonists of neurokinin 1 receptors

Substituted 4-phenyl-pyridine compounds with activity as antagonists of Neurokinin 1 receptors, methods of making these compounds and preparing.

Studies on Organometallic Compounds. II. Facile and Convenient Method for the Synthesis of Idoazines through Iododestannation of Trimethylstannylazines

Trimethylsatannyl and bis(trimethylstannyl) derivatives of pyridine, quinoline, and isoquinoline were prepared from the corresponding halo and dihalo (chloro or bromo) derivatives and trimethylstannyl sodium, which was generated in situ from chlorotrimethylsatannane and sodium.These stannyl derivatives readily underwent iododestannation on treatment with iodine to produce the corresponding iodo and diiodo derivatives of pyridine, quinoline, and isoquinoline, respectively, in good yields.Keywords -trimethylsannylazine; bis(trimethylstannyl)azine; iodoazine; diiodoazine; iododestannation; trimethylstannyl sodium; chlorotrimethylstannane

STANNYLATION-IODINATION REACTION ON PYRIDINE NUCLEI. A FACILE METHOD FOR SYNTHESIS OF IODOPYRIDINES AND IODOQUINOLINES.

Pyridines and quinolines bearing trimethylstannyl substituent at 2-, 3-, or 4-position were synthesized by the reaction of the respective chloro or bromo derivatives with trimethylstannyl sodium, generated in situ from chlorotrimethylstannane and sodium, in the range of 61-88percent yields.Upon treatment with iodine, these trimethylstannyl derivatives smoothly underwent iododemetallation to give the corresponding iodo derivatives of pyridine and quinoline in satisfactory yields.