286374-42-3

Upstream product

• 222835-54-3 N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-4-benzyloxy-1-iodo-6-nitro-2-naphthylamine 
• 286374-31-0 7-amino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester 
• 75-36-5 acetyl chloride 
• 286374-28-5 (6-amino-4-benzyloxy-1-iodo-naphthalen-2-yl)-(3-chloro-allyl)-carbamic acid tert-butyl ester 
• 261763-56-8 7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester 

Downstream Products

• 439599-71-0 [2-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-2-oxoethyl]carbamic acid tert-butyl ester 
• 633302-59-7 4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indol-3-yl)-4-oxobutyric acid 
• 633303-03-4 C₇₀H₇₁Cl₂N₁₅O₁₂ 
• 633303-22-7 C₆₇H₆₅Cl₂N₁₅O₁₁ 
• 633302-83-7 C₆₈H₆₅Cl₂N₁₁O₁₀ 
• 633303-02-3 C₆₅H₆₆Cl₂N₁₂O₁₁ 
• 633303-21-6 C₆₂H₆₀Cl₂N₁₂O₁₀ 
• 633302-67-7 C₆₅H₆₅Cl₂N₉O₁₀ 
• 633302-82-6 C₆₂H₅₉Cl₂N₉O₉ 
• 633303-01-2 C₆₀H₆₁Cl₂N₉O₁₀ 
• 633303-20-5 C₅₇H₅₅Cl₂N₉O₉ 
• 633302-66-6 7-(3-{5-[2-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-2-oxo-ethylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-propionylamino)-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indole-3-carboxylic acid tert-butyl ester 
• 633302-81-5 4-[4-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-4-oxo-butyrylamino]-1-methyl-1H-pyrrole-2-carboxylic acid [2-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-2-oxo-ethyl]-amide 
• 633303-16-9 C₄₇H₅₁ClN₁₂O₉ 

Relevant academic research and scientific papers

Synthesis and cytotoxicity evaluation of novel C7-c7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates.

The C7-C7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamides were synthesized and preliminary anti-cancer evaluation carried out by NCI against three types of cancer cells.

Design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2- dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates.

[carbohydrate structure: see text] The design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates (13, 17) as DNA minor groove binding agents are described.

Solid-phase synthesis of 1-chloromethyl-1,2-dihydro-3H-benz[e]indole (seco-CBI) and a polyamide conjugate

Solid-phase intramolecular aryl radical cyclization onto a vinyl chloride allows the synthesis of 1-chloromethyl-1,2-dihydro-3H-benz[e]indole (seco-CBI), a structure related to the pharmacophores of CC-1065 and duocarmycin SA. A representative unsymmetric