222978-32-7Relevant academic research and scientific papers
Diaryl ether inhibitors of farnesyl-protein transferase
MacTough, Suzanne C.,Desolms, S. Jane,Shaw, Anthony W.,Abrams, Marc T.,Ciccarone, Terrence M.,Davide, Joseph P.,Hamilton, Kelly A.,Hutchinson, John H.,Koblan, Kenneth S.,Kohl, Nancy E.,Lobell, Robert B.,Robinson, Ronald G.,Graham, Samuel L.
, p. 1257 - 1260 (2001)
Imidazolemethyl diaryl ethers are potent inhibitors of farnesyl-protein transferase. The SNAr displacement reaction used to prepare these diaryl ethers was amenable to rapid parallel synthesis of FPTase inhibitors. The use of a broad range of c
