22308-12-9

Basic information

• Product Name: 1,3-BIS(TOSYLOXY)-2,2-DIMETHYLPROPANE
• Synonyms: 1,3-Bis(p-toluenesulfonyloxy)-2,2-dimethylpropane 2,2-Dimethyl-1,3-propanediol Ditosylate Neopentyl Glycol Ditosylate;NEOPENTYL GLYCOL DITOSYLATE;2,2-DIMETHYL-1,3-PROPANEDIOL DITOSYLATE;1,3-BIS(TOSYLOXY)-2,2-DIMETHYLPROPANE;1,3-BIS(P-TOLUENESULFONYLOXY)-2,2-DIMETHYLPROPANE;Bistosyloxydimethylpropane
• CAS NO: 22308-12-9
• Molecular Formula: C₁₉H₂₄O₆S₂
• Molecular Weight: 412.52
• Mol File: 22308-12-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 119.0 to 123.0 °C
• Boiling Point: 568.9°Cat760mmHg
• Flash Point: 297.9°C
• Appearance: /
• Density: 1.254g/cm³
• Vapor Pressure: 2.27E-12mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 1,3-BIS(TOSYLOXY)-2,2-DIMETHYLPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BIS(TOSYLOXY)-2,2-DIMETHYLPROPANE(22308-12-9)
• EPA Substance Registry System: 1,3-BIS(TOSYLOXY)-2,2-DIMETHYLPROPANE(22308-12-9)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 22308-12-9(Hazardous Substances Data)

Usage

General Description

1,3-BIS(TOSYLOXY)-2,2-DIMETHYLPROPANE, also known as di-p-toluenesulfonyloxymethylpropane, is a chemical compound commonly used as a reagent in organic synthesis. It is a colorless liquid with a strong, pungent odor, and it is highly flammable. 1,3-BIS(TOSYLOXY)-2,2-DIMETHYLPROPANE is known for its ability to act as a strong acid catalyst and is often used in the synthesis of various organic compounds. It is also used as a reagent in the preparation of pharmaceuticals and agrochemicals. Additionally, this chemical is known for its potential environmental and health hazards, and proper safety precautions should be taken when handling and storing it.

InChI:InChI=1/C19H24O6S2/c1-15-5-9-17(10-6-15)26(20,21)24-13-19(3,4)14-25-27(22,23)18-11-7-16(2)8-12-18/h5-12H,13-14H2,1-4H3

Upstream product

• 79-37-8 oxalyl dichloride 
• 75885-59-5 2,2-dimethylcyclopropane-1-carboxylic acid 
• 5722-11-2 rac-2,2-dimethylcyclopropanecarbonitrile 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 98-59-9 p-toluenesulfonyl chloride 
• 6315-52-2 1,2-bis-tosyloxyethane 

Downstream Products

• 5722-11-2 rac-2,2-dimethylcyclopropanecarbonitrile 
• 33632-46-1 3,3-dimethyl-1,5-benzodioxepin 
• 61971-69-5 1-(3,5-Bis-trifluoromethyl-phenyl)-1-(2,2-dimethyl-cyclopropyl)-ethanol 
• 61971-68-4 1-(2,2-Dimethyl-cyclopropyl)-1-(4-trifluoromethyl-phenyl)-ethanol 
• 59671-39-5 1-(2,2-Dimethyl-cyclopropyl)-1-phenyl-ethanol 
• 76207-24-4 (3,3-dimethylcyclobutyl)methyl-4-methylbenzene-1-sulfonate 
• 75017-17-3 (3,3-dimethylcyclobutyl)methanol 
• 50675-57-5 dl-2,2-dimethylcyclopropane-1-carboxylic acid chloride 
• 75885-59-5 2,2-dimethylcyclopropane-1-carboxylic acid 
• 82777-32-0 2,2-dimethyl-3-phenylsulphonyl-1-tosyloxypropane 
• 16462-89-8 2,2-dimethyl-1-phenylsulphonylcyclopropane 
• 121955-71-3 5,5-dimethyl-2-phenylthio-1,3-diselenane 
• 37608-93-8 4,4-dimethyl-1-phenylpentan-1-one 
• 82777-31-9 Toluene-4-sulfonic acid 2,2-dimethyl-3-phenylsulfanyl-propyl ester 

Relevant articles and documents

Probing hyperconjugation experimentally with the conformational deuterium isotope effect

Hyperconjugation underlies many chemical phenomena of fundamental and practical importance. Owing to a great deal of interest in the anomeric effect, anomeric-like hyperconjugative effects have been thoroughly investigated in oxygen-containing systems. However, such interactions in the second- and third-row chalcogens are less well-understood and have generated some controversy. Here, we show that the conformational deuterium isotope effect, in combination with Saunders isotopic perturbation method, permits sensitive and direct experimental probing of the conformational equilibria in dioxane, dithiane, and diselenane analogues by variable-temperature, dynamic NMR spectroscopy. We find that the magnitude of the conformational deuterium isotope effect is 252.1, 28.3, and 7.1 J/mol (±10%) for the oxygen, sulfur, and selenium analogues, respectively. These results reveal the periodic trend for hyperconjugation in the chalcogens, which reflect a decreasing n x→σC-H(D) interaction throughout the period, as supported by IR spectroscopy and in agreement with DFT calculations and a natural bond order analysis.

Substituted pyrazolo-piperazines as casein kinase 1 δ/ε inhibitors

The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.

INHIBITORS OF ACETYL-COA CARBOXYLASE

The present invention relates to compounds that act as acetyl-CoA carboxylase (ACC) inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.