66688-49-1

Usage

Uses

Used in Organic Synthesis:
1,3-Diiodo-2,2-diMethylpropane is used as a reagent in the synthesis of other organic compounds, particularly for introducing the iodoform functional group into organic molecules. Its ability to serve as a source of the CHI3 group makes it a valuable component in various chemical reactions.
Used in Disinfection and Antisepsis:
Iodoform is utilized as a disinfectant and antiseptic due to its mild antimicrobial properties. It has been historically employed as a topical antiseptic for minor wounds and cuts, helping to prevent infection and promote healing.
However, it is important to note that the use of iodoform as a topical antiseptic has declined in recent years. This is due to the emergence of more effective and less toxic alternatives that have taken precedence in modern medicine and healthcare practices.

InChI:InChI=1/C5H10I2/c1-5(2,3-6)4-7/h3-4H2,1-2H3

Upstream product

• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 74-88-4 methyl iodide 
• 22308-12-9 1,3-bis((p-toluenesulfonyl)oxy)-2,2-dimethylpropane 
• 68900-52-7 3-Iodo-2,2-dimethylpropyl methylphenylphosphinate 
• 1619-62-1 2,2-dimethylmalonic acid diethyl ester 
• 53555-41-2 2,2-dimethylpropane-1,3-diyl dimethanesulfonate 

Downstream Products

• 37608-93-8 4,4-dimethyl-1-phenylpentan-1-one 
• 1296204-15-3 1,3-bis(4-methoxybenzenethio)-2,2-dimethylpropane 
• 17229-30-0 2,2-dimethylcyclopropyl phenyl sulfide 
• 92362-63-5 2,2-dimethyl-1,3-bis(phenylthio)propane 
• 1392825-38-5 (3-iodo-2,2-dimethylpropyl)(4-methoxyphenyl)sulfane 
• 1392825-34-1 (3-iodo-2,2-dimethylpropyl)(phenyl)sulfane 
• 1392825-35-2 3,3-dimethylthiochroman 
• 1392825-36-3 (2,2,5,5-tetramethylhexane-1,6-diyl)bis(phenylsulfane) 
• 13145-56-7 1,4-bis(4-tolyl)butane-1,4-dione 
• 24314-35-0 1,4-bis(4-chlorophenyl)butane-1,4-dione 
• 495-71-6 phenacylacetophenone 
• 76207-24-4 (3,3-dimethylcyclobutyl)methyl-4-methylbenzene-1-sulfonate 
• 75017-17-3 (3,3-dimethylcyclobutyl)methanol 

Relevant academic research and scientific papers

9-AMINOMETHYL SUBSTITUTED TETRACYCLINE COMPOUND

The present invention relates to 9-aminomethyl substituted tetracycline compounds represented by formula (I), or pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, as well as a method for preparing these compounds and a pharmaceutical composition comprising the same. The present invention relates also to a use of these compounds in the preparation of a medicament for the treatment and/or prophylaxis of tetracycline drug-sensitive disease. wherein, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7, R8, R9a, R9b, R10, R11, R12, R13a and R13b are each independently as defined in the description.

9-AMINOMETHYL SUBSTITUTED TETRACYCLINE COMPOUNDS

The present invention relates to 9-aminomethyl substituted tetracycline compounds represented by formula (I), or pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, as well as a method for preparing these compounds and a pharmaceutical composition comprising the same. The present invention relates also to a use of these compounds in the preparation of a medicament for the treatment and/or prophylaxis of tetracycline drug-sensitive disease. wherein, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7, R8, R9a, R9b, R10, R11, R12, R13a and R13b are each independently as defined in the description.

PHOTOSTIMULATED REACTIONS OF NEOPENTYL IODIDES WITH CARBANIONS IN DMSO BY THE SRN1 MECHANISM

Neopentyl iodide, 1, reacted under photostimulation with several carbanionic nucleophiles in DMSO.With acetone enolate ion only reduction and dimerization occured, but good yields of substitution products have been obtained with acetophenone, 5, and anthrone, 9, anions as nucleophiles.Nitromethane anion, 7, does not react with 1 under irradiation, but good yields of the substitution products are obtained when the photostimulated reaction is carried out in the presence of acetone enolate ions (entrainment reaction).Inhibition experiments by p-dinitrobenzene and by the radical trap TEMPO, suggest that these reactions occur by the SRN1 mechanism of nucleophilic substitution.The photostimulated reaction of 1,3-diiodo-2,2-dimethylpropane, 15, with 5 gave the disubstitution product 17 and the reduced monosubstitution product 18.It has been found that the monosubstitution product 16 (in which iodine is retained) is not an intermediate of these reactions. 1-iodoadamantane, 12, is more reactive (ca. 4.9 times) than 1 in competitive experiments toward 5 and under photostimulation.

Acceleration of the 4-exo radical cyclization to a synthetically useful rate. Cyclization of the 2,2-dimethyl-5-cyano-4-pentenyl radical

The title radical, formed in the reaction of the corresponding bromide with Bu3SnH, cyclizes in a 4-exo fashion to give the (3,3-dimethylcyclobutyl)cyanomethyl radical. At 50°C, the rate constant for cyclization is 1.9 x 104s-1.

Synthesis of metallacyclobutanes and metallacyclobutabenzenes of molybdenum and tungsten

Reactions of 1,3-bis(bromomagnesio)-2,2-dimethylpropane or 1-magnesacyclobutabenzene with either dichloromolybdenocene or dichlorotungstenocene have given the corresponding four-membered metallacycles of both metals.

A Thermolysis Study of Poly(trimethylene phenylphosphinate) and Poly(2,2-dimethyltrimethylene phenylphosphinate). NMR and X-ray Structure of 2-Oxo-2-phenyl-4,4-dimethyl-1,2-oxaphospholane

Thermal decomposition of poly(trimethylene phenylphosphinate) (2) and poly(2,2-dimethyltrimethylene phenylphosphinate) (2a) to 2-oxo-2-phenyl-1,2-oxaphospholane (3) and 2-oxo-2-phenyl-4,4-dimethyl-1,2-oxaphospholane (3a), respectively, has been described and the mechanism of their formation discussed.The X-ray crystal structure of oxaphospholane 3a has been determined and compared to its preferred conformation in solution inferred form 1H and 13C NMR data.Compound 3a crystallized in the monoclinic space group C2/c with eight molecules per unit cell of dimensions a = 26.688(5) Angstroem , b = 7.612(1) Angstroem, c = 11.305(3) Angstroem, and β = 98.88(2) deg.The stereochemistry of another decomposition product of 2a, namely, 4,4-dimethyl-2,6-diphenyl-1,2,6-oxadiphosphorinane 2,6-dioxide (4a), has also been deduced from its NMR data, and the mechanism of its formation is discussed.